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Headlines > Preclinical Research

CRL on the prowl for Chinese M&As in world’s future science hub

16-Sep-2014 - Charles River Labs (CRL) has singled out China as an area of “disproportionate growth” in biologics R&D and says it is on the hunt for preclinical acquisitions in the region....

CRL plans M&As ahead of surge in discovery outsourcing

15-Sep-2014 - Half of drug discovery will eventually be outsourced as the service area goes the way of contract toxicology, according to the CEO of Charles River Laboratories (CRL).

Charles River to lay off up to 30 employees following NCI contract termination

08-Sep-2014 - Early phase CRO (contract research organization) Charles River Laboratories will lay off between 26 and 30 employees following the US National Cancer Institute’s decision to terminate a contract in which...

Shifting pipelines drive AMRI to expand protein expression services

05-Sep-2014 - AMRI has added protein expression and purification services to its drug discovery services citing the shift in pipelines towards larger molecule drugs as a driver.

Layoffs possible as Ricerca Biosciences in discussions to be acquired, CEO says

03-Sep-2014 - Ohio-based CRO (contract research organization) Ricerca Biosciences is holding “ongoing discussions with several parties” about the possible sale of one or more of its divisions or the entire company, CEO...

Zirconium best for imaging mAbs but needs programme, say European orgs

02-Sep-2014 - European organisations representing academic CROs and nuclear medicine researchers have established an accreditation programme for a novel Zirconium-PET imaging technique, used in early development of monoclonal antibodies.

Crown Bio: New in vitro technology could revolutionise drug discovery

02-Sep-2014 - Increasing the predictivity of in vitro systems could cut the costs of drug development and shift preclinical research away from animal models, according to Crown Bioscience.

Breed lab mice with wild for better neuro research say scientists

29-Aug-2014 - The drive for homogenous animal models in preclinical research has robbed mice of useful behavioural traits, say scientists.

Harlan looks to corner NCI grantees lost by Charles River

21-Aug-2014 - News of the discontinuation of the National Cancer Institute’s (NCI) Animal Production Program has led Charles River Laboratories rival Harlan to vie for the market of grantees that still need...

How to speed up development: share work with rivals, say scientists

21-Aug-2014 - Drug developers should add their early-stage discoveries to an open-source database or pay a fine to cut wasted time duplicating results, say researchers.

Organovo: 3D printed liver tissue to challenge current toxicity models

20-Aug-2014 - A 3D printed human liver system could offer better informed risk-based decisions earlier in the drug development process than with current in vitro models, according to developers Organovo.

What’s next for gene editing? After ‘knock-out’, time for ‘knock-in’

19-Aug-2014 - Horizon Discovery says the gene editing tool CRISPR used to engineer its human cell lines is exploding the possibilities of screening for preclinical customers.

Evotec teams with Shire on Fabry's disease as pharma interest in orphans grows

13-Aug-2014 - Evotec has partnered with Shire to develop inhibitors against Fabry’s disease and says such collaborations will grow as Big Pharma increasingly looks towards rare diseases.

CRL nears 85% capacity use, but says sector pricing won't improve yet

11-Aug-2014 - Charles River Laboratories is approaching its optimal capacity utilisation but says pricing will not improve until the rest of the preclinical CRO industry follows suit.

Biosimilar preclinical demand growing as US market beckons, says Harlan

07-Aug-2014 - US demand for biosimilar preclinical services is expected to rocket on the back of the US FDA’s acceptance of Sandoz’s biosimilar filing, according to Harlan Laboratories.

NIH toxicology contract renewed for MRIGlobal despite tightening budget

06-Aug-2014 - The tightening federal budget is increasing competition between research institutes and academia when it comes to preclinical toxicology testing, according to MRIGlobal.

SRI International wins $49m NIH contract to study new HIV, AIDS therapies

29-Jul-2014 - SRI International was awarded a seven-year, $49m contract from the NIAID (National Institute of Allergy and Infectious Diseases), which is a division of the NIH (National Institutes of Health), for...

Philanthropist gives $650m to Broad Institute for psychiatric research

24-Jul-2014 - Philanthropist Ted Stanley has gifted $650m to the Broad Institute as part of a wider attempt to galvanize research on psychiatric disorders and bring new treatments to market. 

News in brief

ABL buys French testing services lab for global reach

23-Jul-2014 - US CMO Advanced Bioscience Laboratories (ABL) has bought French immunogenicity services firm Platine Pharma citing additional global reach as the driver for the deal.

Harlan joins with French CRO to deliver more preclinical services

17-Jul-2014 - Preclinical CRO Harlan Laboratories has partnered with French CRO Fluofarma to strengthen the companies’ drug discovery and translational medicine services.

Charles River loses $12m National Cancer Institute contract

14-Jul-2014 - The US National Cancer Institute (NCI) recently terminated a contract with Charles River Laboratories (CRL) to supply rodents for cancer research.

Peakdale adds discovery offering to PE-backed testing services group

08-Jul-2014 - Pharma services firm Peakdale Molecular has joined with two UK environmental testing providers to form Concept Life Sciences in a private-equity backed agreement.

Petition calls on FDA to amend informed consent requirements

03-Jul-2014 - The Center for Responsible Science  has asked the US FDA to adopt informed consent rules which ensure that trial participants know the experimental drugs they receive may be unsafe or ineffective....

Lonza says stem cell reprogramming makes for better preclinical models

25-Jun-2014 - Lonza has launched a new stem cell reprogramming and maintenance system that has already been used to support US NIH and pharmaceutical company preclinical drug development projects.

Crown: improving animal irradiation can unlock failed drug candidates

24-Jun-2014 - The ability to pinpoint radiotherapy in animal testing could give failed cancer drug candidates a new lease of life, says preclinical CRO (contract research organisation) Crown Biosciences.

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