SUBSCRIBE

Breaking News on Contract Research, Manufacturing & Clinical Trials

Headlines > Preclinical Research

Read more breaking news

 

 

Arcxis accelerates DNA preparation

By Dr Matt Wilkinson , 19-Sep-2007

US-based Arcxis Biotechnologies has launched a new device to enable automated nucleic acid preparation from up to eight biological samples in 15 minutes.

The latest offering from Arcxis, the Lysix Workstation 808, was launched yesterday at the Discovery 2 Diagnostics 2007 meeting in Philadelphia, US and enables fast and reproducible isolation and purification of both RNA and DNA from biological sources.


With ever increasing throughput being delivered by analysis techniques such as gene expression and genotyping experiments using microarrays and multiplexed PCR (polymerase chain reaction) systems, laboratory bottlenecks have started to shift from the analysis of samples to the preparation steps.


Nucleic acid sample preparation is commonly conducted using spin column technologies that can be somewhat laborious and expensive, taking about 10 minutes per sample.


The spin-column procedure is somewhat difficult to automate as the systems use centrifuges to isolate the DNA before elution.


The new workstation uses disposable micro purification cards to purify the DNA or RNA in high yield, enabling eight samples to be purified in 15 minutes with no user intervention.


"The Lysix Workstation changes the way a modern laboratory operates," said Howard Goldstein, CEO of Arcxis.


"It removes the tedium of day after day sample preparation - freeing the researcher to generate a greater amount of cleaner starting material for demanding analysis such as sequence & organism detection, genotyping and gene expression."


Because the system is fully automated it removes the variability that can be introduced into purification procedures by workers conducting repetitive steps.


"This product reflects our longer term strategy of providing modern sample preparation devices to accelerate drug discovery research and clinical diagnostics," Goldstein added.


In addition, the system has a small footprint, freeing up important laboratory space for other instrumentation.


The company expects to start shipping the workstation by the end of October and will be supported by a full range of consumables and reagents to support the isolation of mRNA, total RNA and genomic DNA.