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Drugs moving into the clinic: 1

05-Jan-2007

The first in a new series of periodic roundups of drugs that have moved from preclinical research into clinical testing via the announcement of a Phase I trial or an application for a trial to industry regulators.

Sponsor Name Indication Mechanism
Enzon Pharmaceuticals & Santaris SPC2968 Oncology Hypoxia Inducible Factor 1 alpha (HIF-1 alpha) antagonist - tagetting angiogenesis, cell proliferation, apoptosis, cell invasion
Celsus Laboratorie Intimatan Anti- coagulent: For example, to prevent blood clots during cardiac surgery (replacing heparin) heparin cofactor II agonist
CoGenesys Neugranin decrease infection in patients receiving myelo- suppressive anti-cancer drugs long-acting form of Granulocyte Colony Stimulating Factor (G-CSF)
BN Immuno- Therapeutics MVA-BN(R)-HER2 Oncology - breast cancer vaccine Induce multi-pronged immunity as well as anti-tumor activity
Medivir MV-701 osteoporosis, osteoarthritis, rheumatoid arthritis, Paget's disease and certain tumours causing bone metastases Cathepsin K inhibitor

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