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The evaluations and emerging trends in study design and their impact on the different phases of drug development are described in this pamphlet. Highlights include: Emerging technologies and their impact on different phases of drug development, alternative study designs in safety pharmacology and a review of industry standards. The Safety Pharmacology group at LAB Research will highlight how they improved timelines with an established process for regulatory submissions. The document reviews Safety Pharmacology models including: Cardiovascular Investigations, Respiratory Safety Pharmacology, Neurological examinations, and Gastrointestinal Assays.