RNAi tools

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Dharmacon, a US supplier of RNA and RNA-interference research
products, announced today it has launched Cell Cycle siARRAY, a
collection of ready-to-use siRNA duplexes designed to knock down
112 genes involved in cell cycle regulation.

Dharmacon, a US supplier of RNA and RNA-interference research products, announced today it has launched Cell Cycle siARRAY, a collection of ready-to-use siRNA duplexes designed to knock down 112 genes involved in cell cycle regulation.

The Cell Cycle siARRAY expands on Dharmacon's customer-tested platform to support a genome-wide siRNA library.

Announcing the launch at the 'siRNA in Drug Discovery & Development conference' in California this week, Stephen Scaringe, CEO and CSO of Dharmacon commented: "The Cell Cycle siARRAY, like our other siARRAYs, guarantees gene silencing with 97 per cent probability."

According to the company, using RNA-interference (RNAi) to knockdown or silence genes is an increasingly popular method for rapidly discovering critical information on gene function and target identification.

Dharmacon created proprietary algorithms (SMARTselection) to first select siRNA sequences to silence specific genes and then pool the top four siRNA duplexes into SMARTpools. This SMART technology was used to develop the new Cell Cycle siARRAYS, along with previous arrays for tyrosine kinases, insulin signaling pathways and other gene silencing systems for drug discovery research.

Related topics: Preclinical Research

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