BioForce Nanosciences of the USA has been granted a US patent covering nanoscale arrays useful in identifying target materials or for characterising molecular interaction events.
The patent details methods for the creation and analysis of miniature deposition domains placed on a substrate to form a molecular nanoscale array. This molecular array may be scanned using Atomic Force Microscopy or other detection methods to analyse molecular recognition events and the effect of introduced agents on defined molecular interactions. The approach can be carried out in a high-throughput format, allowing rapid screening of thousands of molecular species in a solid-state array.
The company's founder, Eric Henderson, claims that the method "is truly a novel and superior means of biomolecular analysis [as it] does not require labelling of the deposition material or the target sample, and may also be used to deposit large size molecules without harming them. This is a revolutionary concept and procedure for biomolecular analysis, giving way to new opportunities that will rapidly advance biological research, as well as other industrial areas."
BioForce intends to apply the technology, under the NanoPro banner, to the areas of protein-protein interaction profiling, disease identification and drug discovery.