LIT spectrometer pushes back sensitivity barrier

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A linear ion trap (LIT) spectrometer that is up to 10 times more
sensitive than current systems will be launched later this year by
Applied Biosystems/MDS SCIEX

A linear ion trap (LIT) spectrometer that is up to 10 times more sensitive than current products on the market will be launched at this year's International Mass Spectrometry Conference in Edinburgh, Scotland at the end of this month.

Applied Biosystems and partner MDS SCIEX claim that the 4000 Q TRAP LC-MS/MS (liquid chromatography-mass spectrometry/) system offers significant improvements in workflow and data quality to researchers working with proteins and small molecules.

"Essentially, the 4000 Q TRAP system combines experiments that previously required two separate mass spectrometry technology platforms or were too difficult to automate and integrate,"​, according to Applied Biosystems. As a result, it offers researchers the opportunity to obtain richer data, more cost-effectively and from fewer runs, said the firm.

The machine allows triple quadrupole scan modes with ion trap scans to be conducted in a single run.

In the proteomics laboratory, the 4000 Q TRAP system is able to rapidly identify and measure post-translational modifications (PTM) at low levels from complex biological samples in a single LC/MS/MS run. In drug discovery and development, it will allow the rapid identification, confirmation and quantitation of metabolites at extremely low levels in a single experiment, according to Applied Biosystems.

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