Genomics tool launched by MRC geneservice
launched a gene-silencing library - based on small interfering RNA
(siRNA) - that covers 90 per cent of the genome of the fruitfly
Drosophila melanogaster which is widely used in genetic
studies.
MRC geneservice said that using the library, researchers can study the function of specific genes through genome-wide screens - a first step in shedding new light on disease processes and possible drug targets. The library was originally developed by UK company Cyclacel.
The new Drosophila RNAi library covers 13,600 genes and complementsMRC's whole-genome siRNA library for the nematode worm Caenorhabditis elegans another genetic model.
Dr Tom Weaver, chief executive of MRC geneservice said that having researchers can now get access to RNA interference (RNAi) libraries of the two main model organisms used in functional genomic studies.
The RNAi mechanism in Drosophila is similar to C elegans allowingprocessing of long double-stranded RNAs (dsRNAs) into siRNAs when transferred into living cells.
Dr Weaver explained: "This method of silencing genes is far morecost-effective than using chemically synthesized siRNAs or avector-based strategy. Coupled with our high throughput production this means that we offer researchers exceptional value for money."
MRC geneservice also offers researchers an optional custom dsRNA production service for specific requirements.
