mPLC expands into solubility testing

Related tags High performance liquid chromatography

Microfluidics company Nanostream has introduced a new range of
cartridges designed specifically for quantitative applications such
as solubility assessment and dissolution testing using its micro
parallel liquid chromatography (mPLC) system.

The company has pioneered the use of mPLC with its Veloce system - introduced last year - that matches the performance and functionality of conventional high performance liquid chromatography (HPLC), while offering increased throughput and significant savings in sample and solvent consumption.

The new Brio 4208 cartridge series accommodates larger sample volumes and when used alongside the Veloce achieves 2 per cent peak area reproducibility for 2,400 samples analysed in 100 runs across 24 columns of a single cartridge.

"Applications such as solubility, dissolution testing and formulations studies require greater peak area reproducibility in each separation than other analytical applications [and] the Brio 4208 cartridge series was designed to meet these requirements,"​ said Nanostream. The result is that scientists get more reliable data.

Compared to Nanostream's standard Brio 4207 cartridge series, which accommodates sample volumes of 0.4 to 1.0 uL, sample reservoirs in the Brio 4208 cartridge series can be filled with 3 to 5 ul to achieve greater precision in sample analysis. Like the 4207 series, the 4208 series is currently available with 8 cm columns.

"Our customers have requested improved peak area precision so that they can expand the utility of the Veloce system to new areas such as dissolution and formulations studies,"​ said Gene Dantsker, vice president of technology at Nanostream.

Each reusable Brio cartridge enables 2,400 liquid chromatography separations. The polymer-based cartridges incorporate twenty-four columns packed with standard (C18) stationary phase material to achieve reversed phase separations. Typical flow rates per column for each cartridge are 2 to 20 ul per minute, which significantly reduces solvent consumption.

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