Solubilising excipient gets green light in Japan

- Last updated on GMT

Related tags: Pharmacology

Eastman Chemical Co's Vitamin E TPGS has been approved as a
pharmaceutical excipient for oral drug formulations in Japan by the
Japanese government's Ministry of Health, Labour and Welfare.

Eastman's Vitamin E TPGS ((d-alpha-tocopheryl polyethylene glycol 1000 succinate) is a multifunctional excipient that acts as a drug solubiliser and a bioavailability enhancer, increasing the absorption of water-insoluble drugs, as well as the efficacy of drugs that are otherwise difficult for the body to absorb. Already used as a pharmaceutical excipient in Europe and the United States, Eastman Vitamin E TPGS has been formulated in various oral drug applications including immunosuppressants, HIV protease inhibitors and anticancer drugs. For example, the excipient is a key component in GlaxoSmithKline's HIV protease inhibitor Agenerase (amprenavir). Dr Julian Parratt, pharmaceutical business development manager at Eastman Chemical Company Europe, said: "Pharmaceutical companies operating worldwide can now commercialise products in Japan using this drug delivery technology." Approval of an excipient in all three of the world's top drug markets - North America, Japan and Europe - makes it easier for companies to develop drug products that use it because the same formulation can be filed for approval in each territory. For oral delivery, Eastman Vitamin E TPGS enhances drug efficacy by improving the solubilisation or emulsification of the drug in the finished dosage form and/or through formation of a self-emulsifying drug delivery system (SEDDS) in the stomach. Studies have shown that in some instances Eastman Vitamin E TPGS functions to improve the permeability of a drug across cell membranes by inhibiting P-glycoprotein (P-gp), thus enhancing absorption of a drug through the intestinal wall and into the bloodstream. External links to companies or organisations mentioned in thisstory: Eastman Chemical Company

Related news

Show more

Related products

show more

The Effect of Tamping Force on Bi-Layer Tablets

The Effect of Tamping Force on Bi-Layer Tablets

JRS PHARMA | 15-Aug-2020 | Technical / White Paper

Formulation of bi-layer or multi-layer tablets enables the combination of two or more drugs that may be incompatible or maybe intended for delivery at...

Single-Pass Tangential Flow Filtration

Single-Pass Tangential Flow Filtration

BioContinuum™ Platform - MilliporeSigma | 01-Aug-2020 | Application Note

Tangential flow filtration (TFF) is widely used in the biopharmaceutical industry for downstream processing applications. Typical TFF steps concentrate...

Related suppliers

Follow us

Products

View more

Webinars