Millipore launches new tangential flow filtration device

By Staff Reporter

- Last updated on GMT

Related tags Volume Cell membrane Manufacturing

Millipore launch its version of a tangential flow filtration (TFF)
device for the filtration of monoclonal antibodies and other
therapeutic proteins that form an integral part of the drug
discovery process and development cycle.

Millipore's launch is the third generation of a technology that is used for clarifying, concentrating, and purifying proteins. With this product aimed at drug researchers amongst others, the improved efficiently in purifying large volumes of protein-containing solutions will accelerate drug screening and improve sample preparation.

Manufactured by an automated, computer controlled process the design of Pellicon 3 cassettes can withstand process pressures of up to 80 psi and reverse pressures up to 30 psi.

Each cassette incorporates a rigid end cap that protects the membrane surface from impacts and potential damage.

The end cap's integral seals eliminate the need for external gaskets between each device thus simplifying installation. Pellicon 3 devices can be sanitised with 0.5N NaOH at 50°C up to 50 hours.

Millipore's Ultracel PLC membranes offer low fouling and low protein binding for high product retention, recovery and yield.

Ultracel PLC membranes are constructed of a regenerated cellulose membrane cast on a microporous substrate for a uniform, robust structure, with high integrity and greater resistance to back pressure.

Pellicon 3 cassettes are designed for use in research, process scale-up/scale-down, applications development and full-scale manufacturing.

Available in four sizes (88 cm2, 0.11 m2, 0.57 m2, and 1.14 m2), the design and automated manufacturing process of the Pellicon 3 cassettes provides unbeatable performance consistency and enhanced linear scalability between cassette sizes.

Related topics Preclinical Research

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