Sigma-Aldrich launches first commercially available proteomics standard

By Wai Lang Chu

- Last updated on GMT

Related tags Proteomics

Sigma-Aldrich launches the first commercially available proteomics
standard in which allows researchers to better assess proteomics
strategies, troubleshoot protocols and normalise results from day
to day and lab to lab.

Developed in collaboration with the Association of Biomolecular Resource Facilities (ABRF) Proteomics Standards Research Group (sPRG), the Universal Proteomics Standard provides a complex mixture of 49 HPLC-purified human source or human sequence recombinant proteins, each present at 5 pmols.

Results of the study were presented in February 2006 at the annual meeting of the ABRF.

The Universal Proteomics Standard is a response to the need of the Proteomics community for a complex reference standard and anticipating the utility of this particular mixture following completion of the study.

"The Universal Proteomics Standard brings a much needed resource to the Proteomics community,"​ said Dale Peluso, Sigma-Aldrich's Market Segment manager for Quantitative Proteomics.

"It was a privilege to work with the ABRF sPRG in the development of this important research tool, and we look forward to future opportunities to work with other groups on projects such as this."

The Universal Proteomics Standard is a useful tool for standardising and/or evaluating proteomics analysis conditions prior to analysis of complex protein samples.

It can also be used to bracket critical experimental datasets, thereby confirming the robustness of the analysis method.

In addition, laboratories generating or comparing data derived from poorly defined samples may use it as an external reference to assist with the evaluation of results.

Sigma Aldrich say that the Universal Proteomics Standard may facilitate the comparison of mass spectrometric or other proteomic data that is generated in different labs using a variety of analytical strategies and instruments.

The standard was evaluated by more than 100 independent proteomics laboratories worldwide in an independent study to assess the analytical capabilities of participants and compare the strengths of various analytical strategies.

In post-genomic era, functional genomics have performed to understand complex biological processes.

Proteomics, as a tool for comprehensive analysis of proteins, has been used for protein expression, localisation, post-translation modification and protein-protein interaction.

Since protein expression is dynamically controlled, the quantitative information is important to address the function of proteins

Related topics Preclinical Research

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