Waters and Advion combine technologies in deal
agreement in which the two companies intend to combine products and
offer life scientists enhanced capabilities.
Under the terms of the agreement, Advion intend to combine its TriVersa NanoMate chip-based infusion technology with the Waters Synapt High Definition MS System (HDMS) with the intention to maximise the amount of information researchers can extract from their samples
The collaboration believes the amount of information researchers can extract from samples can be multiplied by combining Advion's nanoelectrospray chip-based sample introduction technology with Waters' ion mobility-based separation provided by the Synapt HDMS System. Financial terms of the deal were not disclosed.
TriVersa NanoMate is a system that integrates LC/MS, fraction collection and chip-based infusion in one platform.
The TriVersa gives proteomics and small molecule researchers the ability to obtain greater than 10 times more information from their sample.
The system speeds the discovery process by allowing extra time to analyse complex components not easily characterised on a chromatographic time scale.
The system also allows interrogation of samples using on-line LC/MS and infusion of LC fractions.
"A prerequisite for many investigations of this type is the ability to maintain the native conformation of protein or peptide ions into the gas phase," said Dr Jack Henion, co-founder and Chief Scientific Officer and Chairman of Advion BioSciences.
"This is typically achieved through the use of neutral pH solvents and low infusion flow rates; an area where the TriVersa NanoMate system can provide demonstrable benefits in terms of ease-of-use and reproducibility."
Waters' Synapt HDMS system incorporates three travelling-wave devices to provide distinct functions.
The first traps and releases packets of ions whilst the second separates ions according to their ion mobility. The third transfers ions to the oa-Tof for mass analysis.
The Trap, Separation and Transfer function is a reproducible and controllable process, which can occur at time frames compatible with ACQUITY and nanoACQUITY UPLC systems.
"The Synapt HDMS System has attracted significant interest from leading biological researchers wishing to exploit its unique combination of high-sensitivity ion mobility and tandem mass spectrometry to provide information that is beyond the capabilities of conventional mass spectrometers, namely its ability to probe the size and shape of ions," said Dr. Alan Millar, HDMS Program Manager at Waters Corporation.
