Collette to show "revolutionary" granulation machine

By Nick Taylor

- Last updated on GMT

Related tags: Gea pharma systems, Particle size distribution, Pharmacology

GEA Pharma Systems' Collette unit will present Consigma, its new
continuous high shear granulation and drying system, at the
Interpack exhibition in Düsseldorf later this month.

The machine is capable of doing particle design in addition to having the capacity to mimic traditional batch granulation. Adoption of continuous processes would be welcomed by sections of the industry, particularly at the FDA. The FDA has stated that it believes pharmaceutical companies should be doing more to convert to more efficient continuous processes. In a white paper on pharmaceutical manufacturing improvement the FDA stated that "pharmaceutical manufacturing operations are inefficient and costly…Low efficiency is predominantly due to 'self imposed' constraints in the system…These constraints keep the system in corrective action mode."​ Collette claims that Consigma will consistently produce higher quality results than its competitors, with Griet Van Vaerenbergh, PDC lab manager at Collette, describing it as "revolutionary​". Speaking to Wim Van der Goten,​ GEA Pharma Systems sales director, said: "All systems that were presented up till now were either semi-continuous processes or included process elements where "back -mixing" was possible. Plug flow is required to control every detail of the process​. "Consigma is a real continuous process without back-mixing. It includes an extremely compact continuous High Shear Granulator which can inline dry mix and granulate powders to a desired content uniformity and particle size distribution.​" This should reduce rejections in the tableting process, meaning "tablet presses run more efficiently, at maximum speed with hardly any weight adjustments required​" according to Collette. The superior results are attributed to the machine's continuous production set-up and 'risk based approach​' to good manufacturing practice. To ensure that the granulation process runs smoothly it can be continuously monitored using an optional inline measurement of critical quality attributes which are relayed back to the control system. One Consigma machine can run 500g in R&D but also has the capacity to run clinical trial, launch size, and any production scale batches. There is no process scale-up when using Consigma, which Collette claims will enable companies to bring products to market more quickly and for less cost. Consigma is aimed at R&D and production teams and it should conveniently fit into companies existing set-ups, said the company. It is a quarter of the size and lighter than a conventional granulation machine and consequently can be relatively easily wheeled in and connected to the power and air supply. The system uses the principal "wash off-line" for cleaning in which "contaminated parts are removed in a contained way and immediately replaced by clean parts​" Mr Van der Goten told Machine parts are then taken off-site to be cleaned. Interested parties will have the opportunity to take a look at the system at Interpack, which this year takes place on 24-30 April.

Related news

Show more

Related products

show more

Strategies to Achieve Successful Approval & Launch

Strategies to Achieve Successful Approval & Launch

Catalent Pharma Solutions | 03-Sep-2020 | Data Sheet

There are several key considerations to how companies should approach commercial-scale manufacturing that may aid the success of their biologic’s launch...

Lactium, your ally to manage day to day stress

Lactium, your ally to manage day to day stress

Ingredia | 27-Aug-2020 | Product Presentation

Stress has been called the ‘health epidemic of the 21st century’ by the World Health Organization. Increasingly, consumers are looking for safe, reliable...

The Effect of Tamping Force on Bi-Layer Tablets

The Effect of Tamping Force on Bi-Layer Tablets

JRS PHARMA | 15-Aug-2020 | Technical / White Paper

Formulation of bi-layer or multi-layer tablets enables the combination of two or more drugs that may be incompatible or maybe intended for delivery at...

Related suppliers

Follow us


View more