Caliper introduces updated LabChip systems

By Dr Matt Wilkinson

- Last updated on GMT

Related tags Molecular biology Dna

Caliper Life Sciences has launched two new microfluidic-based electrophoresis instruments designed to address the separation needs of proteomic and genomic researchers.

The new systems, the LabChip GX and LabChip GXII have been designed to replace the widely adopted LabChip 90 and combine Caliper's robust separation and assay technologies with higher throughput, extended walk away time and more economical plate processing.

Caliper's Microfluidics technology enables researchers to thoroughly analyse samples in a matter of seconds rather than minutes, eliminating workflow bottlenecks and improving efficiency, as well as eliminating the need to handle time consuming SDS page gels.

The advanced data management software supplied with the instruments allows users to view results in various formats, such as electropherogram, virtual gel view or in tabular form that can be easily exported into various spreadsheet packages for further analysis.

"With applications ranging from protein therapeutics research to gene expression analysis to genotyping of transgenic mice, the LabChip GX and GXII represent an integral component of Caliper Life Sciences' overall strategy of developing products that bridge the in vitro - in vivo translational gap,"​ said Rick Bunch, Microfluidics Product Manager for Caliper Life Sciences.

"The LabChip GX and GXII provide high quality, accurate, and reproducible data that enable researchers to accelerate their discovery efforts, while saving time and money."

Both systems are compatible with 96 and 384 well plates, with the LabChip GX having been designed as a low cost entry system targeting the needs of genomics researchers. The GX analyses RNA integrity at a resolution down to 5 base pairs and a sensitivity of 0.1ng/ul to ensure high quality samples for RT-PCR (real time polymerase chain reaction), microarray gene expression and resequencing applications.

The LabChip GX II replaces the widely adopted LabChip 90 and has been designed to provide precise and consistent separation and analysis of protein and nucleic acid samples.

The GX II can quantify the molecular weight, concentration and purity of a protein sample in less than 40 seconds and thoroughly analyse a 96 well plate of protein samples in less than an hour.

The GX II's predecessor, the LabChip 90 has been found to greatly enhance the development of antibody-based therapeutics with its ability to quantify size, titre, purity, and fragmentation.

By enabling a higher level of automation than the Labchip 90, the GX II should enable scientists to more efficiently explore the effect of multiple variables in parallel - a process which can be prohibitively expensive and time-consuming using manual methods.

This approach can lead to the development of robust protein expression methods and accelerate high throughput screening, crystallography, and analytical analyses that require large amounts of protein.

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