Chinese hamster ovary (CHO) clones have varying nutritive requirements and some media are more suited for certain applications than others, which mean that to optimise the process the most appropriate formulation must be selected.
To help companies make these selections SAFC has launched its CHO cGMP (current good manufacturing practice) Media Library, which can be accessed by clients and allows them to screen 20 formulations.
Archie Cullen, vice president of global commercial and technical operations at SAFC Biosciences, said: "We have successfully developed a program that we believe efficiently allows clients to screen a robust offering of media formulations through the CHO Library to quickly identify the best starting point for every application, while also reducing concerns around scale-up by having the formulations already produced to cGMP.
“This capability demonstrates SAFC Biosciences' 'best fit' approach to providing solutions personalised to the specific requirements of our customers and their applications."
New formulation launched
News of the service was accompanied by the launch of a new media formulation EX-CELL CD CHO Fusion, which is featured in the library and expands SAFC’s offering.
The new formulation has been developed to be a chemically defined animal-component free scaleable platform media that can meet production requirements across multiple CHO cell lines.
In addition the formulation quickly adapts to most CHO cell lines, meaning it provides a consistent starting point. These traits mean that the formulation: “can reduce timelines and costs typically related to media screening, development and optimization efforts for multiple CHO-based projects”, according to SAFC.