Cobra Biologics and Alligator Bioscience extend partnership

By Melissa Fassbender

- Last updated on GMT

(Image: iStock/markusblanke)
(Image: iStock/markusblanke)
Cobra Biologics has been re-contracted by Alligator Bioscience to support cell line development for an immune-oncology antibody.

The CDMO announced the drug development partnership extension followings its success developing a cell line for the mAb, ADC-1-13.

Specifically, Alligator has requested additional support from Cobra to develop the cell line for production of a new drug candidate ADC-1015 – a bispecific immune activator.

Cobra initially announced​ its involvement in manufacturing immuno-oncology antibody ADC-1013 as part of Alligator’s Phase I trial in advanced solid tumors in May 2015.

The study assessed the safety, pharmacokinetics, and pharmacodynamics of ADC-1013 in up to 40 patients across sites in the UK, Sweden, and Denmark.

As Biopharma-Reporter.com reported at the time, the partnership was significant as it showed regulators accepted UCOE-based cell line engineering.

UCOE (Ubiquitous Chromatin Opening Element) vectors are used in the company’s MaxXpress platform to insert genes into DNA cells.

Cobra will use this expression system in addition to a historically documented master cell bank (CHO-S) and chemically defined media moving forward. According to the company, the combination delivers times savings in cell line development and a clone selection process suitable for GMP manufacture.

Related news

Show more

Related products

show more

Pulmonary Delivery of Orally Inhaled Therapeutics

Pulmonary Delivery of Orally Inhaled Therapeutics

Content provided by Catalent Pharma Solutions | 19-Oct-2023 | Product Brochure

New classes and indications of orally inhaled therapeutics are rapidly expanding, with the development pipeline increasingly featuring both large and small...

Addressing Challenges with Clinical In-Use Testing

Addressing Challenges with Clinical In-Use Testing

Content provided by Lonza | 12-Oct-2023 | White Paper

Lonza Drug Product expert Léa Sorret PhD explores Clinical In-Use Testing of Biotherapeutics in this white paper. Léa shares her expertise and describes...

Manufacturing Drugs with Highly Potent APIs

Manufacturing Drugs with Highly Potent APIs

Content provided by Altasciences | 28-Sep-2023 | White Paper

In this issue of The Altascientist, we examine the critical considerations for the safe and compliant manufacture of drugs with highly potent APIs (HPAPIs),...

Related suppliers

Follow us

Products

View more

Webinars