Nestle licenses Codexis' enzyme platform and protein drugs for $14m

By Gareth Macdonald

- Last updated on GMT

Gettyimages/Leonid Andronov
Gettyimages/Leonid Andronov

Related tags Enzyme Pharmacology Pre-clinical development

Nestle Health Science has licensed a protein engineering platform from Codexis in a $14m deal that includes an option to co-develop a phenylketonuria drug candidate called CDX-6114.

The agreement grants the Swiss food and beverage company’s unit the right to use Codexis’ tech – known as CodeEvolver – to discover biotherapeutic protein candidates for the treatment of metabolic disorders.

In addition to the $14m upfront, the deal stipulates that Codexis receives payments based on the achievement of clinical development milestones and regulatory approval. The Californian firm is also entitled to royalties on sales.

Nestle will also use the CodeEvolver platform to novel enzymes for use by its consumer care and medical nutrition businesses.

CDX-6114 is a preclinical candidate being developed for the treatment of phenylketonuria. Under the agreement, Codexis will fund the agent through to Phase I clinical trials at which point Nestle has the option to license it for further development and commercialization.

Nestle also has the right of first negotiation for other unspecified current candidates in Codexis’ pipeline as well as others it identifies over the next five years.

The Swiss company joins UK drug firm GSK, which licensed rights to use CodeEvolver in 2014​, and US counterpart Merck & Co, which forged a similar deal the following year​.

Related news

Show more

Related products

show more

Increasing the Bioavailability of Oncology Drugs

Increasing the Bioavailability of Oncology Drugs

Content provided by Lonza Small Molecules | 13-Nov-2023 | White Paper

Oral tyrosine kinase inhibitors (TKIs) are a class of cancer drugs that can be highly susceptible to issues with solubility in the gastrointestinal tract

Efficient Freezing & Storage of Biopharmaceuticals

Efficient Freezing & Storage of Biopharmaceuticals

Content provided by Single Use Support | 06-Nov-2023 | White Paper

Various options exist for freezing biopharmaceutical bulk material, but selecting the most effective and efficient approach for each cold chain can be...

Manufacturing Drugs with Highly Potent APIs

Manufacturing Drugs with Highly Potent APIs

Content provided by Altasciences | 28-Sep-2023 | White Paper

In this issue of The Altascientist, we examine the critical considerations for the safe and compliant manufacture of drugs with highly potent APIs (HPAPIs),...

Follow us


View more