Regeneron releases ‘big data’ resource for global health research

By Maggie Lynch

- Last updated on GMT

(Image: Getty/undefined undefined)
(Image: Getty/undefined undefined)

Related tags Research Clinical research Big data Data collection Data integrity Data management Regeneron Gsk

Regeneron and UK Biobank announce human sequencing data resource for global research and to accelerate improved patient care through outcome algorithms.

Collected from 50,000 UK Biobank participants, the exome sequence data was generated that the Regeneron Genetics Center (RGC) through a collaboration with UK Biobank, Regeneron, and GlaxoSmithKline (GSK). The data is linked to detailed de-identified health records, imaging, and other additional health-related data.

Compiled data from the first 50,000 participants will now be incorporated back into the UK Biobank resource for the global health research community following a brief research period for Regeneron and GSK.

Sequencing was performed by the RGC, one of the world’s largest human genetics sequencing and research programs. The RGC is currently sequencing at a rate of 500,000 exomes per year.

Regeneron, a consortium of biopharma companies including AbbVie, AstraZeneca, Pfizer, and Takeda, will complete the exome sequencing of the remaining 450,000 UK Biobank participants by 2020. As the data is completed it will be released over the next two years.

Aris Baras, senior vice president and head of the RGC said in a statement, “We believe this is the largest open-access resource of exome sequence data linked to robust health records in the world – and this is just the beginning.”

Baras told us, that members of the pharmaceutical industry are using ‘big data’ in multiple sectors of research.

He also said that it is important to note that the volume of data is certainly important and, “the diversity of these datasets in terms of which people, and their records, are included in the larger dataset and the consistency of this data across the entire dataset.”

RGC stated that actionable information is a resource that can be used to accelerate science and improved patient care.

Data resource advances

Regeneron and GSK released a preprint of a manuscript describing findings from an examination of the first 50,000 exomes.

GSK is also incorporating the daily advances in genetics and genomics into its drug research programs to form collaborations and is working closely with other world-leading organizations.

Tony Wood, senior vice president of Medicinal Science and Technology at GSK, said in a statement, “Genetics is playing an increasingly important role in research, and by generating and now integrating these exome data, UK Biobank has some of the richest health and genetics data available for use by the broader scientific community to enhance their understanding and research effort.”

From this data, new disease-related algorithms are provided on asthma, kidney disease, dementia, and Parkinson’s disease.

The exome makeups up to 1-2% of the human genome where the actual protein-coding genes are contained and are believed to have the most relevance for discovering genetic variants that may inform the discovery and development of improved medicines.

Related news

Show more

Related products

show more

ODM and CDASH in CRF design

ODM and CDASH in CRF design

Formedix | 10-Mar-2023 | Technical / White Paper

The lesser-known Operational Data Model (ODM) standard is often overlooked as it's not required by any regulators. So, why should you be interested...

4 Warning Signs Your Research Site Is in Trouble

4 Warning Signs Your Research Site Is in Trouble

Elligo Health Research® | 10-Mar-2023 | Insight Guide

You want your clinical research practice to be a success for your business and your patients, but how can you tell if it’s in trouble? Read this article...

Designing an Optimal APAC Clinical Supply Chain

Designing an Optimal APAC Clinical Supply Chain

Catalent | 08-Mar-2023 | Infographic

With clinical study activity increasing across the Asia-Pacific region, it is important for sponsors—both in APAC and globally—to understand the broader...

How Sponsors Reduce Chaos in Decentralized Trials

How Sponsors Reduce Chaos in Decentralized Trials

Florence Healthcare | 08-Mar-2023 | Insight Guide

89% of research sponsors currently use and expect to continue the use of decentralized technologies and methods, according to our state of the industry...

Related suppliers

Follow us


View more