Ph I CAR-T cell therapy trial to use Horizon Discovery tech

By Melissa Fassbender contact

- Last updated on GMT

(Image: Getty/bluebay2014)
(Image: Getty/bluebay2014)

Related tags: Horizon Discovery, phase I, Clinical trial, IND applications, Technology, CAR-T

The Phase I clinical trial is slated for early 2020 and will be first CAR-T cell therapy clinical trial to use Horizon Discovery’s technology, according to the company.

Celyad, a clinical-stage biopharmaceutical company, has received investigational new drug (IND) approval from the US Food and Drug Administration (FDA) for its autologous NKG2D-based CAR-T cell therapy, CYAD-02, which uses Horizon Discovery’s​ SMARTvector shRNA technology.

The technology uses a SMARTvector short hairpin RNA (shRNA) algorithm to design target shRNA sequences with high specificity to ensure optimal gene silencing, according to the company.

The Phase I dose-escalation trial will involve a preconditioning chemotherapy (CyFlu) in patients with relapse/refractory (r/r) acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). It is expected to begin in early 2020.

Horizon Discovery CEO Terry Pizzie, said in a statement: “We see great potential for shRNA technology in the optimization of next-generation cell therapies. The success of this IND filing is testament to the strength of our relationship with Celyad, and the powerful combination of Horizon’s SMARTvector shRNA platform with Celyad’s CAR-T expertise.”

As per the companies’ agreement, Horizon will receive an undisclosed milestone payment for the successful IND filing.

Related topics: Clinical Development, Phase I-II

Related news

Show more

Related products

show more

Laboratory Solutions for COVID-19 Clinical Trials

Laboratory Solutions for COVID-19 Clinical Trials

Q2 Solutions | 10-Jun-2020 | Clinical Study

As a leading laboratory services organization for trials across the globe, we are proud to partner with clients to support COVID-19 clinical trials. Our...

Parents as Gatekeepers for Children with Cancer

Parents as Gatekeepers for Children with Cancer

PRA Health Sciences | 08-Jun-2020 | Technical / White Paper

The RACE for Children Act will require new drugs intended for adult cancer treatment to also be studied in pediatric cancers when the molecular target...

Related suppliers

Follow us

Products

View more

Webinars