Elsevier developing risk calculator for DDIs ‘aligned with pharma’s needs and challenges’

By Melissa Fassbender

- Last updated on GMT

(Image: Getty/olm26250)
(Image: Getty/olm26250)

Related tags Elsevier Drug-drug interaction Drug development Patient safety

To improve patient safety and reduce risk, Elsevier is developing an improved drug-drug interaction risk calculator in collaboration with several pharma partners, including Boehringer Ingelheim, Eli Lilly, and Servier.

Elsevier’s PharmaPendium team is working with Boehringer Ingelheim, Eli Lilly and Company, Pierre Fabre, Sanofi, and Servier, among others, to develop an updated drug-drug interaction risk calculator (DDIRC).

According to the information analytics company, the calculator will help improve patient safety and outcomes in addition to reducing risk during the drug development process.

Olivier Barberan, director of translational medicine solutions at Elsevier, said the companies have committed to working with Elsevier for two years to provide input on the ways in which they are using the calculator, how they would like to visualize data, in addition to feedback about other capabilities that should be included.

“Working with this wide range of pharma partners allows us to develop new capabilities that support better DDI risk assessment in a way that is aligned with pharma’s needs and challenges,”​ Barberan told us.

The calculator uses information from scientific literature and filings from public regulatory agencies – including the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) – to predict metabolic drug-drug interactions (DDI) between drugs in development and those currently on the market.

“It helps to establish the risks of potential interactions for multiple drugs simultaneously, providing a full risk profile against marketed drugs,”​ he added. “It will deliver accurate, shareable, and actionable insights so researchers can be confident that the drug in development is safe and effective when interacting with potentially hundreds of other drugs—an increasingly difficult task.”

Several factors have led to an increase in adverse drug reactions (ADRs) Barberan said, “however, the most significant is due to the aging populations across the world, and the increases in prescription use.”

According to the company, 9% of Americans over age 55 currently take ten or more drugs, “which greatly increases the likelihood of DDIs and experiencing ADRs,”​ he explained.

The FDA estimates that more than 106,000 people die annually due to ADRs, costing the medical care system an estimated $200bn per year. ADRs are responsible for nearly 197,000 deaths every year in Europe.

Phase one of the update, to be complete in early 2020, will include new workflows and data visualization methods, as well as the ability to integrate proprietary drug or patient data libraries.

The final version will be released in early 2021 and will include a model for predicting transporter-based DDIs, as well as other improvements.

Related news

Show more

Related products

show more

Saama accelerates data review processes

Saama accelerates data review processes

Content provided by Saama | 25-Mar-2024 | Infographic

In this new infographic, learn how Saama accelerates data review processes. Only Saama has AI/ML models trained for life sciences on over 300 million data...

More Data, More Insights, More Progress

More Data, More Insights, More Progress

Content provided by Saama | 04-Mar-2024 | Case Study

The sponsor’s clinical development team needed a flexible solution to quickly visualize patient and site data in a single location

Using Define-XML to build more efficient studies

Using Define-XML to build more efficient studies

Content provided by Formedix | 14-Nov-2023 | White Paper

It is commonly thought that Define-XML is simply a dataset descriptor: a way to document what datasets look like, including the names and labels of datasets...

Related suppliers

Follow us


View more