Boom in number of UK cell and gene therapy clinical trials

By Ben Hargreaves contact

- Last updated on GMT

(Image: Getty/Ktsimage)
(Image: Getty/Ktsimage)

Related tags: Cell therapy, Gene therapy, Cell and gene therapy catapult, Uk, Advanced therapeutics

Year-on-year, the number of trials for advanced therapeutics has doubled, meaning that the UK now represents 12% of all global clinical trials in the area.

The UK is establishing itself as a hub for the development of advanced therapeutics, with employment increasing rapidly​ and financial backing reaching record levels​.

Adding a further feather to the industry’s cap are the latest statistics released by the Cell and Gene Therapy Catapult (CGTC) showing that the number of clinical trials increased by 45% in 2019, compared to the previous year.

In total, there are 127 ongoing trials in the advanced therapies medicinal products (ATMPs) area, representing 12% of ongoing global trials.

Keith Thompson, CEO of the CGTC, noted that the number of trials has been growing by an average of 25% year-on-year since 2013.

However, the report did qualify that the new figures have been generated by a new automated methodology, which uncovered trials missed by previous reviews’ manual searches.

UK seen as a leader

Broader than this, the CGTC noted that there appears to be a growing recognition of the UK’s position as a leader in the field, with a majority of commercially sponsored trials being backed by international organizations.

As the pipeline within the country continues to progress, the proportion of clinical trials that are sponsored by commercial organizations has also increased to 77%, up from 25% in 2013.

In terms of the progression of the trials themselves, the greater part are in the recruitment phase, which is a similar pattern to previous years; however, the CGTC added that there has been a larger than normal shift into this stage of the clinical trial set-up.

Explaining why this is the case, the report stated that this could be as a result of “trials in the UK…quickly moving through planning and regulatory approvals reaching the recruitment phase at a faster rate than previously.”

The targets

In terms of what therapeutic candidates are being progressed and the target, the majority are gene therapies and the most common therapeutic area is oncology.

The focus on oncology (39% of trials) is no surprise given the global outlook​ for this therapeutic area. In addition, the gene therapy area has also experienced landmark approvals, including Novartis’ Zolgensma (onasemnogene abeparvovec)​ and bluebird’s Zyntelgo (autologous CD34+ cells encoding βA-T87Q​​-globin gene)​.

In terms of delivery, in-vivo​ clinical trials are dominated (89%) by gene therapies utilizing adeno-associated viral (AAV) vectors.

The only negative on the results are this reliance on AAV vectors leading to bottlenecks at the leading producers​, with waiting lists for capacity. As the clinical trials move closer to larger scale studies and to commercialization, this will only increase the pressure on supply.

Related news

Show more

Related products

show more

Automating clinical trials for success

Automating clinical trials for success

Formedix | 06-Oct-2021 | Technical / White Paper

This article gives gives a brief overview of why automation is absolutely essential for clinical trial success.

What should a clinical metadata repository do?

What should a clinical metadata repository do?

Formedix | 26-Jul-2021 | Technical / White Paper

Choosing a clinical metadata repository (MDR) software can be a tough task as the capabilities and features of your chosen MDR could make or break your...

Adapting supply chains to new ways of working

Adapting supply chains to new ways of working

World Courier | 15-Jul-2021 | Technical / White Paper

COVID-19 has changed the way we operate. We have adapted our supply chain solutions to meet our clients’ requirements while following World Courier standard...

Empowering Clinical Trial Sponsors with Analytics

Empowering Clinical Trial Sponsors with Analytics

PerkinElmer | 14-Jul-2021 | Technical / White Paper

Is your Clinical Data Review creating problems or solving them? Take Control of Your Data. PerkinElmer Informatics Clinical Solutions, powered by Tibco...

Related suppliers

Follow us


View more