Sun Pharma approved for COVID-19 trial

By Jenni Spinner

- Last updated on GMT

(Gilnature/iStock via Getty Images Plus)
(Gilnature/iStock via Getty Images Plus)

Related tags Clinical trial Investigator COVID-19 Coronavirus

The company has been given the go-ahead to launch clinical research testing Nafamostat as a potential treatment for patients diagnosed with the virus.

India-based Sun Pharmaceutical Industries reports it has received approval from the Drugs Controller General of India (DCGI) to conduct a clinical trial involving treatment of COVID-19 patients with the drug Nafamostat Mesilate. The drug has been approved in Japan for treatment of acute symptoms of pancreatitis and treatment of disseminated intravascular coagulation (DIC).

Dilip Shanghvi, managing director for Sun Pharma, said, “Sun Pharma is constantly evaluating potential targets that can be explored for treating Covid-19 patients. Nafamostat has shown promising data against SARS-CoV-2 virus in in vitro studies conducted by three independent groups of scientists in Europe, Japan and South Korea​.”

We believe it holds promise in the treatment of COVID-19 patients​,” Shanghvi added.

Researchers with the University of Tokyo and Leibniz (Germany) Institute for Primate Research reportedly have demonstrated Nafamostat, dosed in very low concentrations, suppresses a protein (TMPRSS2) that the COVID-19 virus uses to enter human lung cell. Additionally, scientists with Institut Pasteur in South Korea reportedly compared the antiviral efficacy of Nafamostat and 24 other drugs against SARSCoV-2 in in-vitro studies in human lung epithelial derived cells, finding Nafamostat to be the most potent drug.

Currently, three separate clinical trials are underway to test the efficacy of Nafamostat when treating COVID-19 patients. These include a clinical trial being headed by the University of Tokyo Hospital, another by Gyeongsang National University Hospital in South Korea, and a collaborative trial jointly run by University Hospital (Padova, Italy) University of Zurich (Switzerland) and Yokohoma City University in Japan.

In the face of the pandemic and worldwide effort to rapidly discover and develop viable treatment options, Sun Pharma representatives have announced plans to kick off clinical trials as soon as possible. The company reports it has initiated manufacturing of the drug’s active pharmaceutical ingredient (API) and finished Nafamostat at its production facilities in India, also harnessing technology from its Pola Pharma Japan subsidiary.

Related news

Show more

Related products

show more

How a Clinical MDR Helps with Data Quality

How a Clinical MDR Helps with Data Quality

Formedix | 16-Jan-2023 | Technical / White Paper

This article covers the many ways a clinical metadata repository helps with data quality in the clinical trial process, and how it ultimately helps to...

Optimizing Adherence in DCTs

Optimizing Adherence in DCTs

PPD - Decentralized Clinical Trials | 12-Jan-2023 | Technical / White Paper

Prioritizing greater patient-centricity and creating an opportunity to reach unprecedented patient groups, decentralized and hybrid clinical trials are...

PPD is Supporting Complex EU DCTs

PPD is Supporting Complex EU DCTs

PPD - Decentralized Clinical Trials | 05-Jan-2023 | Technical / White Paper

PPD supports European DCTs and clinical trial sponsors with a holistic and comprehensive approach

What should a clinical metadata repository do?

What should a clinical metadata repository do?

Formedix | 14-Dec-2022 | Technical / White Paper

Choosing a clinical metadata repository (MDR) software can be a tough task as the capabilities and features of your chosen MDR could make or break your...

Related suppliers

Follow us


View more