Carrier solution addresses challenging liquid APIs: W.R. Grace

By Jenni Spinner contact

- Last updated on GMT

(Vizerskaya/iStock via Getty Images Plus)
(Vizerskaya/iStock via Getty Images Plus)

Related tags: Active pharmaceutical ingredients, API, API quality, bioavailability, CPhI Worldwide, Manufacturing

The CPhI Worldwide exhibitor will show Syloid XDP, a silica carrier designed to convert liquid, waxy, or oily active ingredients into free-flowing powders.

W.R. Grace has announced plans to debut its Syloid XDP silica at CPhI Worldwide, a hybrid pharmaceutical industry event taking place online until November 19, and in the real world November 9-11 in Milan, Italy. The company’s in-person exhibit is located at Booth 11F26.

Syloid XDP silica is a novel, pharmaceutical-grade novel carrier designed to convert liquid, waxy, or oily active pharmaceutical ingredients (APIs) into free-flowing powders.

We are deeply committed to meeting evolving patient needs through new product innovation,​” said Sandra Wisniewski, president of Grace Materials Technologies. “Giving our customers a new product that helps advance their formulations and deliver patient value is paramount to our objectives as an organization​.”

According to the company, the product (produced using GMP) stands to benefit both drug manufacturers and patients. It reportedly enables conversion of liquid APIs into other, more convenient forms, leading to the ability to produce a wider variety of dosage forms, such as hard capsules, tablets, stick packs, and sachets.

W.R. Grace reports the product is a mesoporous synthetic silica-based processing aid able to absorb up to 1.5 times its weight in liquid while remaining a free-flowing, non-dusty material. It is intended to help formulators address numerous challenges associated with liquid dosage, including stability and bioavailability issues.

Additionally, Syloid XDP is designed to act as a substrate and enable the dry processing of self-emulsifying and self-micro emulsifying drug delivery systems. Manufacturers reportedly can employ the silica to attain improved blend uniformity compared to traditional mixing methods. Handling and downstream processing reportedly are possible without any need for solvents or drying time.

On top of showcasing Syloid XDP, Grace plans to present on excipients, as part of CPhI Worldwide’s Learning Lab series.


CPhI Worldwide 2021 is a hybrid event; the in-person component (expected to host up to 30,000 industry professionals with 1,400 exhibitors) takes place November 9-11 in Milan, and the digital content will be available until November 19. Read here to register or to see a list of sessions, events, and other features.

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