The Chemical Industries Association in the UK has unveiled plans to
develop a database of chemicals marketed in the UK as part of the
industry's preparations for the adoption of the proposed
Registration, Evaluation & Authorisation...
Last year, pharmaceutical companies from India submitted a third of
all the Drug Master Files for active pharma ingredients (APIs)
received in the US, outstripping their international rivals by a
A survey has found that difficulties in swallowing pills is
widespread among adults, but is rarely discussed with doctors and
can prevent some people from taking their medicine. The findings
suggest that pharmaceutical companies should...
A recent trend in drug development has been the re-invigoration of
older pharmaceuticals by developing new versions based on just one
of the two optical isomers of the active compound, a process known
as racemic switching. But critics...
A study which has found significant differences between the adult
and childhood forms of asthma suggests that pharmaceutical
companies may have to rethink their approach to developing new
drugs for the disease.
Large Scale Biology Corp has solved the problem of supplying large
quantities of aprotinin - widely used in the manufacture of
biologic drugs - by developing a recombinant form that is made in
Researchers in the UK have discovered a protein that seems to play
a key role in repairing the DNA of cells. The discovery could lead
to a way of inhibiting malignant cells from repairing themselves
after treatment, potentially improving...
Virologists in China have said that a man suffering from fever and
a respiratory infection is infected with severe acute respiratory
syndrome (SARS), the viral disease that caused nearly 800 deaths
around the world in the first half...
There are fears that a renewed epidemic of severe acute respiratory
syndrome (SARS) could occur in 2004, after initial tests on a
patient with symptoms associated with the disease suggested that
the causative agent was the SARS coronavirus...
France's Nautilus Biotech says that it has achieved a key technical
milestone in a collaboration with Aventis Pasteur, designed to
improve the productivity of the latter's vaccine manufacturing
The international team of scientists working to determine the most
common variations of the human genome have given more details of
the rationale behind the effort, known as the HapMap project, in
the journal Nature (18 December).
Formulation specialist TransForm Pharmaceuticals has licensed a
novel salt form of the antiepileptic drug topiramate to Johnson
& Johnson in a development that provides the first real
validation of its business model.
Germany's third-largest chemicals company Degussa has won the Frost
& Sullivan Product of the Year Award for its L-hydantoinase
enzymatic process for single-step production of L-amino acids, used
in the pharmaceutical, food...
The US Food and Drug Administration (FDA) approved 15 New Molecular
Entities in the current year to 30 September, 2003, setting the
stage to outpace last year's registrations by nearly 20 per cent,
says a report from Cutting...
Australia's Gradipore has brought in external help to find a
solution to the company's manufacturing problems for its
polyacrylamide gels, used for electrophoretic separations in the
life sciences industry.
The amount of pharmaceutical R&D funding headed out-of-house to
research suppliers engaged in drug development work will grow
almost 15 per cent annually for the next five years, nearly double
the anticipated increase in overall...
A US start-up company specialising in biomaterials, 3DMatrix, has
developed a synthetic scaffold product that can be used to create
self-assembling, microscale environments to encourage the growth of
cells in culture.
Molecular Probes of the Netherlands, a specialist in proteomics
tools, took the opportunity presented by the Lab Automation Europe
meeting towards the end of last month to launch a range of new kits
for protein, RNA and DNA analysis.
The pharmaceutical industry is suffering from a raft of problems at
present, from a decline in R&D productivity through patent
expirations and the increasing reluctance of health care systems to
pay for prescription drugs.
De Novo Pharmaceuticals says it has refocused its business from
in-house drug discovery to commercialisation of its proprietary
in silico drug discovery platforms, halving its workforce in
Many drugs cannot be administered orally since they cannot be taken
up in the gastrointestinal tract. All attempts to solve this
problem have thus far resulted in unacceptable risks of side
effects, mainly because the intestinal wall...
It is already well established that microwave energy can be used to
speed up the breakdown of protein molecules by enzymes, the first
stage in protein identification. Now, a collaboration between two
companies is looking to incorporate...
The innovation gap between the EU and the US will not be closed
before 2010 if the present rate of progress continues, according to
new figures contained in the Commission's European innovation
scoreboard for 2003.
A pilot study supported by the European Commission has concluded
that a lack of access to scientific equipment and technology, and
not salaries, is one of the main factors causing the 'brain drain'
of scientists, often from...
Determining the molecular structure of drugs is one of the
foundations of the discovery and development of new medicines and
underpins the synthesis of novel drugs. But will the new generation
of computer-based models for this supplant...