Accelerating Lipid Drug Formulation with the Premier Expert System
Formulation scientists are increasingly pivotal to pharmaceutical product development. They are often faced with the daunting challenge of identifying the most suitable drug delivery platform among a myriad of options and developing and validating robust systems that address the challenges posed by increasingly complex drug candidates. Further, these challenges must be overcome in ever-shortening times frames. Among platforms, lipid-based formulations, in either soft gelatin or liquid hard shell capsule formats, have become a well-established approach that has been shown to improve the bioavailability and reduce the food effects and uptake variability of poorly soluble compounds. Capsugel has developed an enhanced lipid-based formulation approach that moves beyond predictive modeling and excipient high-throughput screening. This system utilizes a database of experimentally generated phase diagrams, providing unique formulation development support and resulting in increased speed to market.