Dow AFFINISOL™ polymers for Solubility Enhancement

Format: External webinar | Document type: Webinar

Dow’s AFFINISOL™ line of excipients include AFFINISOL™ HMPCAS for spray drying applications and AFFINISOL™ HPMC for hot melt extrusion (HME) applications.Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight:• Pharmaceutical grades of AFFINISOL™ HPMCAS• Impact of succinate and acetate substitution levels and molecular weight.• Innovative high productivity HPMCAS polymer that increases spray-drying solids loading by up to 70%AFFINISOL™ HPMC helps to provide a broader operating window, improved melt flow and resistance to color change at elevated temperatures compared to traditional Hypromellose (HPMC). The study shows:• Processing versatility of this polymer in HME• Toxicity of AFFINISOL™ HPMC to be negligible


Kevin O’Donnell Kevin O’Donnell Senior Chemist, R&D
The Dow Chemical Company

William "Trey" Porter III William "Trey" Porter III Senior Chemist, R&D
The Dow Chemical Company

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