Case Study
Film Coating for Taste-masking of an HIV Drug for Pediatrics
MSD evaluated several taste-masking options to coat raltegravir granules, for pediatric dosing. They chose a coating comprised of Surelease®, aqueous ethylcellulose dispersion, in combination with an Opadry® product. Insoluble in water, ethylcellulose acts as the taste-masking agent by delaying the release of the drug in the mouth, while Opadry is used as a pore-former in the coating, which allows immediate release of the drug once in the stomach.
