Case Study

Film Coating for Taste-masking of an HIV Drug for Pediatrics

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Film Coating for Taste-masking of an HIV Drug for Pediatrics

MSD evaluated several taste-masking options to coat raltegravir granules, for pediatric dosing.  They chose a coating comprised of Surelease®, aqueous ethylcellulose dispersion, in combination with an Opadry® product.  Insoluble in water, ethylcellulose acts as the taste-masking agent by delaying the release of the drug in the mouth, while Opadry is used as a pore-former in the coating, which allows immediate release of the drug once in the stomach.

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