Application Note
Internal Standard (IS) Variation Case Studies: Emerging from Three Common IS Challenges
![Internal Standard (IS) Variation Case Studies: Emerging from Three Common IS Challenges](/var/wrbm_gb_food_pharma/storage/images/_aliases/wrbm_product_file/publications/pharmaceutical-science/outsourcing-pharma.com/library/internal-standard-is-variation-case-studies-emerging-from-three-common-is-challenges/16858923-3-eng-GB/Internal-Standard-IS-Variation-Case-Studies-Emerging-from-Three-Common-IS-Challenges.png)
The use of internal standards (IS) is essential for developing and applying liquid chromatography-tandem mass spectrometric (LC-MS/MS) quantitative bioanalytical methods. As bioanalytical knowledge rapidly advances and regulatory requirements continue to harmonize globally, attention has shifted to focus on IS of chromatographic methods.