Case Study

Need help to bring insoluble APIs to the market?

Format: PDF file | Document type: Case Study | Promoted Content

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Dow Pharma & Food Solutions

New AFFINISOL™ HPMC HME​ - Dow has designed a new generation of this cellulosic polymer which maintains the crystallization inhibiting properties of traditional HPMC, but can be extruded over a wide temperature range without the use of plasticizers. Thanks to its low glass transition temperature (Tg) AFFINISOL™ HPMC HME provides drug formulators with new capabilities to formulate amorphous solid dispersions via extrusion processes. This paper reports on two extrusion case studies utilizing BCS Class II Active Pharmaceutical Ingredients (APIs) and AFFINISOL™ HPMC HME.

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