Prioritizing greater patient-centricity and creating an opportunity to reach unprecedented patient groups, decentralized and hybrid clinical trials are becoming more widely adopted. Novel solutions can help reduce patient burden and validate if patients are participating according to study guidelines. PPD’s portfolio of decentralized / adherence technologies include: smart packaging combined with remote monitoring, TeleVisits, virtual sites and mobile sites, direct-to/direct-from-patient shipments, and devices measuring the date and time of a medication event for each delivery method.