Know more: enhance in vivo pharmacology with imaging. Recent tumor model development and informative imaging technologies have enabled the efficient and robust use of orthotopic models. These models have proven to be the most clinically relevant and predictive cancer models. Modalities including FDG-PET, FLT-PET and DCE-MRI allow for the observation of blood flow, vascularity, cell kill and metabolism in the orthotopically-implanted tumor. These readouts enhance the view of your preclinical studies and allow you to make the best decisions to move your drug development and discovery forward.