Technical Papers

Incretins & gastrointestinal hormones

The digestion and absorption of nutrients subsequent to food intake is associated with increased secretion of multiple gastrointestinal (GI) peptides....

Approaches to Analyzing Therapeutic Peptides and Proteins by LC-MS/MS

Covance | 14-Dec-2010 | Technical / White Paper

Covance is committed to delivering world class service, expertise and efficiency to support your drug development needs. In the attached white paper, read...

Rexam Inhalia metering valves thoroughly consistent

Rexam Healthcare | 13-Dec-2010 | Data Sheet

Rexam offers a platform of metering valve for inhalation treatments combining different gasket materials and plastic resin choices. The Inhalia valves...

Protect your sensitive formulation with an airless system

Rexam Healthcare | 06-Dec-2010 | Technical / White Paper

The dermal route is gaining ground in the prescription and OTC markets. However formulations tend to be more sensitive, requiring reliable systems to dispense...

Bile Acids: Beyond Cholesterol Metabolism & Fat Absorption

Although bile acids are important for regulating cholesterol homeostasis through fat digestion, they have in recent years emerged as important signaling...

SAFC's Approach to Productivity and Regulatory Compliance Improvements for Vaccine

SAFC Pharma | 01-Dec-2010 | Case Study

This case study highlights the collaboration between SAFC and Oncolytics Biotech Inc, a Calgary, Canada-based biotechnology company, to address concerns...

Secure Weighing of Potentially Dangerous Compounds

METTLER TOLEDO | 29-Nov-2010 | Case Study

Ferring Pharmaceuticals uses a SKAN HFC-S 1200MT safety cabinet together with an XP2U micro balance from METTLER TOLEDO to weigh-in potentially dangerous...

Recommendations for consistent application of RECIST 1.1

Perceptive Informatics | 22-Nov-2010 | Technical / White Paper

Today, the majority of clinical trials evaluating cancer treatments for objective response or progression of disease in solid tumors use RECIST. The new...

White Paper on Forced Degradation Studies

SGS Life Science Services | 08-Nov-2010 | Technical / White Paper

The stability of a drug product or a drug substance is a critical parameter which may affect purity, potency and safety. This white paper outlines how...

"I need BASi for innovative solutions to Dried Blood Spot sampling."

BASi | 08-Nov-2010 | Technical / White Paper

Reduce animal numbers and refine data with BASi's Dried Blood Spot (DBS) sampling. DBS offers advantages for collection, storage, and shipping of...

Supply Chain Compliance in Global Clinical Research

World Courier | 08-Nov-2010 | Technical / White Paper

A recent study conducted by U.K.-based Medicines and Healthcare Products Regulatory Agency (MHRA) found that a stunning 43% of critical and major product...

BASi Dried Blood Spot Sampling

BASi | 03-Nov-2010 | Technical / White Paper

“I need BASi for innovative solutions to Dried Blood Spot sampling.”Reduce animal numbers and refine data with Dried Blood Spot (DBS) sampling. DBS offers...

Super Refined Polysorbates Reduce Cellular Irritation

Croda Inc | 01-Nov-2010 | Technical / White Paper

Pharmaceutical formulators of topical and parenteral dosage forms often encounter the issues of irritation at the site of application or injection. Croda...

Acute Kidney Injury (AKI) Biomarker Program

Pacific Biomarkers Inc. has launched a new program to investigate the biological and analytical qualities of biomarkers that current literature and experimental...

Optimization of Cell Culture Media for Production of Viral Vaccines

SAFC Pharma | 26-Oct-2010 | Case Study

This case study highlights the collaboration between SAFC and Vivalis, a France-based biotechnology company, to develop serum-free, animal-component free...

Pharmaceutical Grade Waters Purity Without Chemicals

METTLER TOLEDO | 25-Oct-2010 | Case Study

Siemens-Ionpure is leading the way in high purity water production by effectively using Continuous Electrodeionization (CEDI) technology to purify pharmaceutical...

Optimizing capsule counting accuracy

METTLER TOLEDO | 25-Oct-2010 | Case Study

METTLER TOLEDO was approached by a leading gelatin capsule manufacturer to optimize their capsule counting system. For this new capsule bag filling project...

Optimising excipient properties for ODT formulation

Roquette Pharma Solutions | 25-Oct-2010 | Application Note

Compression forces and tablet hardness versus disintegration rate are key formulation factors. It’s just a question of identifying the ODT excipient that...

Method Development and Validation of Caffeine and Paraxanthine in Human Plasma

BASi | 18-Oct-2010 | Technical / White Paper

BASi’s expanded European facility provides contract research services — preclinical, toxicology, bioanalytical, method development and pharmaceutical analysis...

Solvias Scientific Magazine – out now!

Solvias AG - Chemical and analytical development | 13-Oct-2010 | Technical / White Paper

Topics• Improved product quality via NIR – Real-time monitoring of tablet coating thickness dates• Biosimilars – A Selection of updates• High throughput...

Considering the Clinical Supply Chain in Vaccine Trials

Fisher Clinical Services | 12-Oct-2010 | Technical / White Paper

Fisher Clinical Services is a global leader in clinical trial supplies. Today, 50% of FCS projects involve controlled temperature or cold chain products,...

New solutions for the pharmaceutical industry

IMA: 50 years of innovation in processing and packaging machines | 11-Oct-2010 | Data Sheet

Discover IMA Group’s new solutions for the processing and packaging of pharmaceutical products: the Perfima perforated pan, the Xtrema F2000 aseptic filler,...

Custom Manufacturing Driven by Core Competencies at Genzyme Pharmaceuticals

Genzyme Pharmaceuticals | 05-Oct-2010 | Technical / White Paper

With global competition in custom manufacturing dramatically shifting, companies are changing business strategies to extend geographic presence, create...

Frymix II - the new way of aseptic semi-solids processing

Romaco: The best way to get it right – Aseptic filling from Romaco Macofar | 30-Sep-2010 | Data Sheet

The Frymix II from FrymaKoruma is a further development of our successful Frymix vacuum processing technology. The system is designed to meet the stringent...

I Holland & Molecular Profiles lead the way with Anti-Sticking research

I Holland Limited - Tabletting Science | 30-Sep-2010 | Research Study

As part of I Holland's continuing quest to increase understanding of the science behind tabletting, their R & D team have completed a preliminary...

Fujicalin® - Unique Spray Dried Carrier for Liquisolid Systems and Probiotic Tablets that Last 3 Years

Fuji Chemical Industries Co., Ltd. | 29-Sep-2010 | Application Note

Fujicalin® is an excellent carrier for liquisolid systems (up to 12% of Tocopherol acetate load) according to new studies conducted at the University of...

Realise the full potential of your data with Exploristics, the innovative analysis company

Exploristics | 28-Sep-2010 | Technical / White Paper

We provide unique expertise in statistical data analysis and we offer a range of solutions for data management, storage, integration, analysis and visualisation....

Five year trouble free manufacturing for large pharma company

Alkermes Contract Pharma Services | 23-Sep-2010 | Case Study

Alkermes, through the merger with Elan Drug Technologies,to become Alkermes plc,has been developing and manufacturing commercial scale solid oral dosage...

White Paper on USP Elemental Impurities

SGS Life Science Services | 20-Sep-2010 | Technical / White Paper

The USP has completed its revision on how heavy metals testing will be performed for drug products, drug substances, excipients and dietary supplements....

Thorough QT Trials-Traditional & Alternate Designs

SGS Life Science Services | 15-Sep-2010 | Technical / White Paper

Before the Health Authorities give the green light to put a new drug on the market, they generally request a clinical study dedicated to the evaluation...

Product & Process Transfer of a Low Solubility Compound with 6 year OTIF >95%

Alkermes Contract Pharma Services | 14-Sep-2010 | Case Study

Alkermes, through the merger with Elan Drug Technologies,to form Alkermes plc,has been developing and manufacturing commercial scale solid oral dosage...

The 10 Essential Don’ts for Manufacturers to combat Main Street’s ‘New Normal’ and win

CDC Software | 10-Sep-2010 | Technical / White Paper

Many factories are currently engaged in many cost reduction initiatives that are stumbling or have dramatically slowed down. In many cases they continue...

Automated density measurement controls production of sterilization ampoules

METTLER TOLEDO | 06-Sep-2010 | Case Study

CILAG, a Swiss pharmaceutical and fine chemicals company produces, amongst other things, cartridges for a sterilization system. In order to meet tight...

Design and validation of Clinical Rating Scales, Patient Reported Outcomes, Composite Endpoints and Quality of Life Data

Exploristics | 06-Sep-2010 | Clinical Study

These instruments provide vital measures of the effectiveness of treatment as well as the general well-being and physical and psychological state of the...

Exploristics supports the Design and Validation of Clinical Rating Scales, Patient Reported Outcomes, Composite Endpoints and Quality of Life Data

Exploristics | 25-Aug-2010 | Technical / White Paper

Quality of Life, Patient Reported Outcomes, Composite Endpoints and Clinical Ratings Scales have important applications in clinical research and practice....

Greater Process Availability in Lysine Production

METTLER TOLEDO | 23-Aug-2010 | Case Study

Successful manufacture of lysine relies on strict control of dissolved oxygen (DO). For one of the world’s largest lysine producers, switching to optical...

Beyond Plant Visibility to Business Improvement

CDC Software | 17-Aug-2010 | Technical / White Paper

Increasing evidence is pointing to the realization that many plant-wide intelligence initiatives do not lead to the dramatic improvements that the business...

Generate Sales Leads: Free White Paper

William Reed Business Media: Publish your Technical Paper on this Website | 02-Aug-2010 | Technical / White Paper

White papers (or technical papers) are one of the most effective ways to generate leads for your sales team and establish your company’s reputation as...

Why polish and maintain tablet compression tooling?

I Holland Limited - Tabletting Science | 19-Jul-2010 | Data Sheet

Prolong tooling life, prevent punch & die problems and increase your productivity. Read I Holland’s article on the 7 Steps of Punch and Die maintenance....

API Stability and Topical Delivery

Croda Inc | 12-Jul-2010 | Research Study

Pharmaceutical formulators are continually challenged to maximize an API’s chemical profile, stability and performance. In a collaborative study, Croda...

Powerful new technique for protein sizing

Paraytec Ltd | 12-Jul-2010 | Application Note

The biopharmaceutical industry needs new techniques for monitoring the size of therapeutic proteins and monoclonal antibodies. This application note outlines...

Characterization of hydrolysates to enhance CHO cell culture process understanding

SAFC Pharma | 06-Jul-2010 | Case Study

Undefined components, such as protein hydrolysates, are routinely used in biopharmaceutical production to boost the growth and productivity of cells in...

New Cure for Metal Detection Headaches

METTLER TOLEDO | 28-Jun-2010 | Application Note

Increasing productivity and reducing manufacturing costs whilst improving competitiveness and meeting industry compliance needs. See how Safeline’s Tablex-PRO...

Solvias Scientific Magazine – Out now!

Solvias AG - Chemical and analytical development | 28-Jun-2010 | Technical / White Paper

Crystallization – Understanding and developing the processInterview with USP: New method for heavy metals testing <231>Antibody drug conjugates –...

Choose the Right Temperature-Controlled Packaging

World Courier | 23-Jun-2010 | Data Sheet

Choosing proper temperature-controlled packaging from today's wide array of products should form part of a larger 'cost/performance' strategy...

Basic Principles of Freeze Drying

Genevac | 21-Jun-2010 | Technical / White Paper

Available in English, French and German a new white paper from Genevac / SP Scientific provides an informative introduction to the principles behind all...

Take Control of Your Clinical Labels

Almac Group | 16-Jun-2010

LAS is a secure web access workflow management system providing users with instant visibility and control on all their clinical supply labels – greatly...

LC/MS/MS Method Development of Clonidine in Pig Tissue Samples

BASi | 07-Jun-2010 | Technical / White Paper

BASi provides contract research services and specialized instrumentation for in vivo sampling. Download a recent LC/MS/MS method developed for clonidine...

Evaluation of the Dried Blood Spot technique for the quantification of diltiazem in human blood

BASi | 02-Jun-2010 | Technical / White Paper

BASi’s US and European facilities provide contract research services including preclinical, toxicology, bioanalytical, method development and pharmaceutical...

GMP’s best practice with in-process quality control solutions

METTLER TOLEDO | 31-May-2010 | Case Study

The exact mixture and concentration of API and excipients is crucial for consumer health. A tablet or capsule must be pressed or filled with the precise...