Technical Papers

Optimization of Cell Culture Media for Production of Viral Vaccines

SAFC Pharma | 26-Oct-2010 | Case Study

This case study highlights the collaboration between SAFC and Vivalis, a France-based biotechnology company, to develop serum-free, animal-component free...

Pharmaceutical Grade Waters Purity Without Chemicals

METTLER TOLEDO | 25-Oct-2010 | Case Study

Siemens-Ionpure is leading the way in high purity water production by effectively using Continuous Electrodeionization (CEDI) technology to purify pharmaceutical...

Optimizing capsule counting accuracy

METTLER TOLEDO | 25-Oct-2010 | Case Study

METTLER TOLEDO was approached by a leading gelatin capsule manufacturer to optimize their capsule counting system. For this new capsule bag filling project...

Optimising excipient properties for ODT formulation

Roquette Pharma Solutions | 25-Oct-2010 | Application Note

Compression forces and tablet hardness versus disintegration rate are key formulation factors. It’s just a question of identifying the ODT excipient that...

Method Development and Validation of Caffeine and Paraxanthine in Human Plasma

BASi | 18-Oct-2010 | Technical / White Paper

BASi’s expanded European facility provides contract research services — preclinical, toxicology, bioanalytical, method development and pharmaceutical analysis...

Solvias Scientific Magazine – out now!

Solvias AG - Chemical and analytical development | 13-Oct-2010 | Technical / White Paper

Topics• Improved product quality via NIR – Real-time monitoring of tablet coating thickness dates• Biosimilars – A Selection of updates• High throughput...

Considering the Clinical Supply Chain in Vaccine Trials

Fisher Clinical Services | 12-Oct-2010 | Technical / White Paper

Fisher Clinical Services is a global leader in clinical trial supplies. Today, 50% of FCS projects involve controlled temperature or cold chain products,...

New solutions for the pharmaceutical industry

IMA: 50 years of innovation in processing and packaging machines | 11-Oct-2010 | Data Sheet

Discover IMA Group’s new solutions for the processing and packaging of pharmaceutical products: the Perfima perforated pan, the Xtrema F2000 aseptic filler,...

Custom Manufacturing Driven by Core Competencies at Genzyme Pharmaceuticals

Genzyme Pharmaceuticals | 05-Oct-2010 | Technical / White Paper

With global competition in custom manufacturing dramatically shifting, companies are changing business strategies to extend geographic presence, create...

Frymix II - the new way of aseptic semi-solids processing

Romaco: The best way to get it right – Aseptic filling from Romaco Macofar | 30-Sep-2010 | Data Sheet

The Frymix II from FrymaKoruma is a further development of our successful Frymix vacuum processing technology. The system is designed to meet the stringent...

I Holland & Molecular Profiles lead the way with Anti-Sticking research

I Holland Limited - Tabletting Science | 30-Sep-2010 | Research Study

As part of I Holland's continuing quest to increase understanding of the science behind tabletting, their R & D team have completed a preliminary...

Fujicalin® - Unique Spray Dried Carrier for Liquisolid Systems and Probiotic Tablets that Last 3 Years

Fuji Chemical Industries Co., Ltd. | 29-Sep-2010 | Application Note

Fujicalin® is an excellent carrier for liquisolid systems (up to 12% of Tocopherol acetate load) according to new studies conducted at the University of...

Realise the full potential of your data with Exploristics, the innovative analysis company

Exploristics | 28-Sep-2010 | Technical / White Paper

We provide unique expertise in statistical data analysis and we offer a range of solutions for data management, storage, integration, analysis and visualisation....

Five year trouble free manufacturing for large pharma company

Alkermes Contract Pharma Services | 23-Sep-2010 | Case Study

Alkermes, through the merger with Elan Drug Technologies,to become Alkermes plc,has been developing and manufacturing commercial scale solid oral dosage...

White Paper on USP Elemental Impurities

SGS Life Science Services | 20-Sep-2010 | Technical / White Paper

The USP has completed its revision on how heavy metals testing will be performed for drug products, drug substances, excipients and dietary supplements....

Thorough QT Trials-Traditional & Alternate Designs

SGS Life Science Services | 15-Sep-2010 | Technical / White Paper

Before the Health Authorities give the green light to put a new drug on the market, they generally request a clinical study dedicated to the evaluation...

Product & Process Transfer of a Low Solubility Compound with 6 year OTIF >95%

Alkermes Contract Pharma Services | 14-Sep-2010 | Case Study

Alkermes, through the merger with Elan Drug Technologies,to form Alkermes plc,has been developing and manufacturing commercial scale solid oral dosage...

The 10 Essential Don’ts for Manufacturers to combat Main Street’s ‘New Normal’ and win

CDC Software | 10-Sep-2010 | Technical / White Paper

Many factories are currently engaged in many cost reduction initiatives that are stumbling or have dramatically slowed down. In many cases they continue...

Automated density measurement controls production of sterilization ampoules

METTLER TOLEDO | 06-Sep-2010 | Case Study

CILAG, a Swiss pharmaceutical and fine chemicals company produces, amongst other things, cartridges for a sterilization system. In order to meet tight...

Design and validation of Clinical Rating Scales, Patient Reported Outcomes, Composite Endpoints and Quality of Life Data

Exploristics | 06-Sep-2010 | Clinical Study

These instruments provide vital measures of the effectiveness of treatment as well as the general well-being and physical and psychological state of the...

Exploristics supports the Design and Validation of Clinical Rating Scales, Patient Reported Outcomes, Composite Endpoints and Quality of Life Data

Exploristics | 25-Aug-2010 | Technical / White Paper

Quality of Life, Patient Reported Outcomes, Composite Endpoints and Clinical Ratings Scales have important applications in clinical research and practice....

Greater Process Availability in Lysine Production

METTLER TOLEDO | 23-Aug-2010 | Case Study

Successful manufacture of lysine relies on strict control of dissolved oxygen (DO). For one of the world’s largest lysine producers, switching to optical...

Beyond Plant Visibility to Business Improvement

CDC Software | 17-Aug-2010 | Technical / White Paper

Increasing evidence is pointing to the realization that many plant-wide intelligence initiatives do not lead to the dramatic improvements that the business...

Generate Sales Leads: Free White Paper

William Reed Business Media: Publish your Technical Paper on this Website | 02-Aug-2010 | Technical / White Paper

White papers (or technical papers) are one of the most effective ways to generate leads for your sales team and establish your company’s reputation as...

Why polish and maintain tablet compression tooling?

I Holland Limited - Tabletting Science | 19-Jul-2010 | Data Sheet

Prolong tooling life, prevent punch & die problems and increase your productivity. Read I Holland’s article on the 7 Steps of Punch and Die maintenance....

API Stability and Topical Delivery

Croda Inc | 12-Jul-2010 | Research Study

Pharmaceutical formulators are continually challenged to maximize an API’s chemical profile, stability and performance. In a collaborative study, Croda...

Powerful new technique for protein sizing

Paraytec Ltd | 12-Jul-2010 | Application Note

The biopharmaceutical industry needs new techniques for monitoring the size of therapeutic proteins and monoclonal antibodies. This application note outlines...

Characterization of hydrolysates to enhance CHO cell culture process understanding

SAFC Pharma | 06-Jul-2010 | Case Study

Undefined components, such as protein hydrolysates, are routinely used in biopharmaceutical production to boost the growth and productivity of cells in...

New Cure for Metal Detection Headaches

METTLER TOLEDO | 28-Jun-2010 | Application Note

Increasing productivity and reducing manufacturing costs whilst improving competitiveness and meeting industry compliance needs. See how Safeline’s Tablex-PRO...

Solvias Scientific Magazine – Out now!

Solvias AG - Chemical and analytical development | 28-Jun-2010 | Technical / White Paper

Crystallization – Understanding and developing the processInterview with USP: New method for heavy metals testing <231>Antibody drug conjugates –...

Choose the Right Temperature-Controlled Packaging

World Courier | 23-Jun-2010 | Data Sheet

Choosing proper temperature-controlled packaging from today's wide array of products should form part of a larger 'cost/performance' strategy...

Basic Principles of Freeze Drying

Genevac | 21-Jun-2010 | Technical / White Paper

Available in English, French and German a new white paper from Genevac / SP Scientific provides an informative introduction to the principles behind all...

Take Control of Your Clinical Labels

Almac Group | 16-Jun-2010

LAS is a secure web access workflow management system providing users with instant visibility and control on all their clinical supply labels – greatly...

LC/MS/MS Method Development of Clonidine in Pig Tissue Samples

BASi | 07-Jun-2010 | Technical / White Paper

BASi provides contract research services and specialized instrumentation for in vivo sampling. Download a recent LC/MS/MS method developed for clonidine...

Evaluation of the Dried Blood Spot technique for the quantification of diltiazem in human blood

BASi | 02-Jun-2010 | Technical / White Paper

BASi’s US and European facilities provide contract research services including preclinical, toxicology, bioanalytical, method development and pharmaceutical...

GMP’s best practice with in-process quality control solutions

METTLER TOLEDO | 31-May-2010 | Case Study

The exact mixture and concentration of API and excipients is crucial for consumer health. A tablet or capsule must be pressed or filled with the precise...

Video Demonstrates Safety-certified Bunsen Burner

Integra Biosciences | 17-May-2010 | Data Sheet

INTEGRA have released a new online video that demonstrates why the FIREBOY™ is the Safety Bunsen Burner of choice for laboratories seeking high application...

Pharming It Out: Clinical Trial Strategies to Support Product Licensing

The aftershocks of last year’s economic crisis have created financial challenges for drug developers of all sizes.Young biotech companies face a shortage...

See what’s new in pharmaceutical processing and packaging

IMA: 50 years of innovation in processing and packaging machines | 03-May-2010 | Data Sheet

The new solutions from the IMA Group for the pharmaceutical industry: discover the Adapta capsule filler, the Xtrema F2000 aseptic filler, the Uniline...

Super Refined Excipients - Stability Enhancement of Softgels

Croda Inc | 30-Apr-2010 | Case Study

A current challenge of softgel manufacturers is the prevention of gelatin crosslinking. Excipient purity is now believed to have a positive effect on the...

Quality assurance of pharmaceuticals

Metrohm – customized analysis for the pharmaceutical industry | 19-Apr-2010 | Data Sheet

Metrohm’s new brochure «Pharmaceutical analysis» is a highly valuable compendium to get an overview of the most important parameters determining the quality...

Starting Dose Selection in First-in-Human Trials

SGS Life Science Services | 14-Apr-2010 | Technical / White Paper

Following the life-threatening adverse event that occurred after the FIH adminis­tration of a CD28 super-agonist antibody, early testing in humans was...

Fermentation Technology: Cooking Up New Therapeutics

SAFC Pharma | 14-Apr-2010 | Case Study

Fermentation technology offers the pharmaceutical industry a reliable, powerful and economic source for chemical and biological therapeutic drugs. Silvian...

A New Approach to Outsourced Drug Development: How Sponsor-CRO Clinical Delivery Alliances Improve Performance

As sponsor companies struggle to replace the revenue loss threatened by generics, they are searching for more cost-effective ways to increase the number...

PHARMACEUTICAL GAS ANALYSIS: A NEW TREND IN THE REGULATORY FOCUS

SGS Life Science Services | 31-Mar-2010 | Technical / White Paper

More attention is being focused on gases role as an excipient in pharmaceutical development. Download SGS’s Technical Bulletin and learn more about cGMP...

Predictable Quality Management with Good Weighing PracticeTM (GWP®)

Mettler Toledo International Inc. | 31-Mar-2010 | Data Sheet

Operating a weighing system in compliance with any current quality management system requires a good understanding of the regulations, of the parameters...

Making clinical trials easier and more successful in the UK and in Ireland

Pharmalys Ltd | 29-Mar-2010

The UK has become a leading country in clinical research, thanks to its very good infrastructure and numerous initiatives implemented by the authorities...

Generate sales leads with a good white paper

William Reed Business Media: Publish your Technical Paper on this Website | 24-Mar-2010 | Technical / White Paper

White papers (or technical papers) are one of the most effective ways to generate leads for your sales team and improve your company’s reputation as an...

New solutions for the pharmaceutical industry

IMA: 50 years of innovation in processing and packaging machines | 17-Mar-2010 | Data Sheet

Discover IMA Group’s new solutions for the processing and packaging of pharmaceutical products: the S250 Smart tablet press, the Xtrema F2000 aseptic filler...

Integra Biosciences - Innovations In Liquid Handling Bulletin

Integra Biosciences | 01-Mar-2010 | Data Sheet

INTEGRA Biosciences has announced a technical bulletin that describes its latest innovations in the area of liquid handling including the new PIPETBOY...