White Paper
The Effect of Tamping Force on Bi-Layer Tablets
![The Effect of Tamping Force on Bi-Layer Tablets](/var/wrbm_gb_food_pharma/storage/images/_aliases/wrbm_product_file/publications/pharmaceutical-science/outsourcing-pharma.com/resources/excipients-raw-materials-and-intermediates/the-effect-of-tamping-force-on-bi-layer-tablets/11686937-1-eng-GB/The-Effect-of-Tamping-Force-on-Bi-Layer-Tablets.jpg)
Formulation of bi-layer or multi-layer tablets enables the combination of two or more drugs that may be incompatible or maybe intended for delivery at different rates. As part of combining the layers in a multi-layer tablet, layers that precede a second or third layer must be lightly compressed or “tamped” before the successive layer is applied. The amount of tamping force applied has a direct effect on the strength of the bond created between the two layers. This paper analyzes the effect of varying the tamping force on the resulting bond between layers.