How to reduce crosslinking and ensure fast dissolution in soft caps
Crosslinking is a natural phenomenon occurring in gelatin that negatively impacts soft capsules, reducing their stability and prolonging their dissolution time.
Delivery technologies
Pulmonary Delivery of Orally Inhaled Therapeutics
New classes and indications of orally inhaled therapeutics are rapidly expanding, with the development pipeline increasingly featuring both large and small molecules and systemic indications.
In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule
Invivo: Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first...
ReciBioPharm - An optimized Plasmid DNA platform to accelerate the path to clinic and commercialization
Assessing key parameters of the upstream process to achieve high titer while maintaining desired integrity Customizing the downstream process to address the different needs from supercoil plasmid and linear isoform A platform approach with integrated...
Small Molecule development – getting it right
Small Molecule drug development is something more and more ambitious emerging pharmaceutical companies are taking on from end to end. But this path can be fraught with risk.
APAC Region Distribution Considerations for Clinical Trial Supplies
The Asia-Pacific (APAC) region has been a steadily growing area for sponsors to conduct clinical studies. Maintaining continuity of trial supply across APAC can be tricky, but critical to the success of studies being conducted across the region. What are...
A Better Approach, for Better Pain Trials
Pain studies face unique challenges. For one, pain severity can only be truly assessed by the patients themselves. The controlled substances that are often used as experimental treatments in these studies bring stricter drug accountability requirements....
Unlocking the Power and Versatility of Plant-Based Softgels
While plant-based diets continue to grow in popularity, the desire to live and act more sustainably and healthfully is on the rise.
Is clinical development prepared for the paradigm shift caused by COVID-19?
The COVID-19 pandemic has – without warning – turned clinical operations on its head, forcing the clinical research community to re-evaluate how to manage clinical trials. Global Biopharmaceutical companies, medical device companies, and contract...
Pellicon® Single-Pass Tangential Flow Filtration
Versatile ultrafiltration technology for biopharmaceutical processes requiring flexibility, capacity, and efficiency.
The impact of PAT tools for aseptic manufacturing processes
Telstar case study. What is the impact of leading-edge innovative developments on the process analytical technology field for pharmaceutical systems and aseptic manufacturing processes? Discover how PAT Tools can easily help in the daily pharmaceutical...
Flow Cytometry Services
We are an established leader in flow cytometry services for clinical trials. Our technologies and solutions meet the growing global demand for enhanced discovery capabilities, and the subsequent complex and comprehensive data sets required for drug...
Local lab Data Management
When a clinical trial requires local or point-of-care laboratory testing, managing the resulting data can be a significant burden to both the sponsor and the investigator sites. There are several factors driving the need for local lab support during...
How to get reproducible DNA amplification
DNA concentration, mastermix preparation, temperature management: Doing PCR like a pro can be more complex than it seems.The Eppendorf infographic helps you to stay on top of your PCR.Our tips and...
UPLC Analysis of Methoxy & 2-Hydroxypropoxy in Hypromellose
Because of its use in the pharmaceutical and food industries, the USP has established standards relating to the amount of methoxyl and 2-hydroxypropoxyl substitutions in hypromellose. The USP...
Article on Viral Clearance for Biopharmaceuticals
Viral clearance studies are mandated prior to entering clinical trials and for commercial launch of biopharmaceuticals. These studies are a key component of risk mitigation to reduce the...
Customized Biosimilarity Analytical Testing from Catalent
Assessment of biosimilar molecules requires an orthogonal analytical approach. Any one particular analytical technique is not able to fully define the physical and biological characteristics of...