Excipients, raw materials and intermediates

Understanding the hidden value of quality

Thermo Fisher Scientific – Production Chemicals and Services | 16-Jan-2023 | Technical / White Paper

The raw material supply is too vital to leave to chance, and quality-related supply chain activities are cornerstones to your success.

Specific Excipient Requirements in Continuous Tablet Manufacturing

JRS PHARMA | 30-Aug-2022 | Technical / White Paper

Continuous Manufacturing Technology continues to gain importance in pharmaceutical manufacturing.

The Effect of Tamping Force on Bi-Layer Tablets

JRS PHARMA | 15-Aug-2020 | Technical / White Paper

Formulation of bi-layer or multi-layer tablets enables the combination of two or more drugs that may be incompatible or maybe intended for delivery at...

TCC TB - Tricalcium citrate as excipient for direct compression

Jungbunzlauer | 05-Nov-2018 | Technical / White Paper

TCC TB is a tricalcium citrate tetrahydrate designed to function as a direct compression excipient. It combines exceptional compression characteristics,...

Accelerate your supply chain as pressures intensify

William Reed | 17-Sep-2018 | Technical / White Paper

Food, Drink and Non-Food manufacturers are under pressure. Range reviews, massive retail mergers, the backlash against plastic packaging and the ongoing...

Customized Fill Release in Gelatine Soft Capsules

Gelita AG | 07-May-2018 | Application Note

From rapid release in the stomach for e.g. analgesics to enteric release for fills with unpleasant aftertaste – GELITA delivers the respective gelatine...

NEW…sugarcane derived USP Squalane from Aprinnova

APRINNOVA – A joint venture of AMYRIS and NIKKOL Group | 26-Feb-2018 | Product Brochure

To date, topical formulation chemists have been restricted to using Squalane derived from the harvesting of shark livers. Neossance Squalane USP, derived...

Why managing variability?

SIO/ADM | 02-Oct-2017 | Research Study

Significant efforts are necessary to develop an active pharmaceutical ingredient (API). It is therefore risky to expose this API to poorly characterized...

GELITA® Gelatine for State-of-the-Art Delivery Systems

Gelita AG | 21-Aug-2017 | Technical / White Paper

The latest development of the GELITA Competence Team is GELITA® RXL R2 that takes the reduced cross-linking (RXL) concept provided by GELITA® RXL one step...

Influence of Different Lubricants on Tableting Characteristics and Dissolution Behavior

JRS PHARMA | 14-Jun-2017 | Application Note

Apart from their desired effect of reducing the ejection force and punch adhesion, lubricants also have a considerable influence on the tablet hardness,...

VALSYNTHESE – Custom phosgenation under GMP

Valsynthese SA | 01-Mar-2017 | Technical / White Paper

Phosgene is a powerful reagent allowing the straightforward synthesis of key intermediates such as chloroformates, acid chlorides, and carbamoyl chlorides....

Producing the perfect soft gel

Leading manufacturer of gelatine and collagen peptides | 17-Jan-2017 | Technical / White Paper

This white paper outlines the key considerations to ensure gelatin is enhanced for soft gel formulation, efficient gel production and optimal API delivery...

Choosing the Right Size Sphere

Colorcon Inc. | 21-Nov-2016 | Technical / White Paper

Choosing the right size sugar sphere, for a multiparticulate dosage form is imperative.  Size matters; not only to achieve a robust formulation and efficient...

Experience foam for topical drug delivery

Gattefossé | 14-Nov-2016 | Technical / White Paper

Pharmaceutical foams are becoming more popular probably due to more topical medicines being switched to OTC and the need to innovate and differentiate...

Optimise the texture of pharma gel formulations

Stable Micro Systems | 31-Oct-2016 | Technical / White Paper

Convenient, comfortable and highly effective, gel-based pharmaceuticals are booming. For optimal robustness and efficacy, texture is critical. Discover...

Challenges and SEPPIC solutions for moisture sensitive formulation

SEPPIC | 24-Oct-2016 | Technical / White Paper

One of the challenges of the formulators is to develop stable formulations which protect API from moisture. To find solutions and different ways of protecting...

pH measurement: Six technical tips

Metrohm – customized analysis for the pharmaceutical industry | 10-Oct-2016 | Technical / White Paper

The pH value is one of the most important and therefore also one of the most frequently measured quantities in analytical chemistry. Sometimes a simple...

Time and cost savings in pharmaceutical production with high performance equipment cleaning after processing EUDRAGIT® coatings

Evonik Health Care | Recorded the 25-Oct-2016 | Webinar

The cleaning of coating equipment for pharmaceuticals can make up a significant portion of production costs, particularly in commercial-scale processes....

Elemental Impurity Analysis in Pharmaceuticals – The Road To Implementation of ICH Q3D

Butterworth | 13-Sep-2016 | Technical / White Paper

The International Conference of Harmonisation (ICH) guidance document on elemental impurities, Q3D, reached step 4 in December 2014, meaning the final...

Impact of Extrusion Process Parameters on Drug Recovery and Dissolution

Information not available | 04-Jul-2016 | Technical / White Paper

This technical paper studies the impact of extrusion process parameters on the performance of solid dispersions of Ritonavir, a poorly soluble antiretroviral...

The Effect of Silicification on the Roller Compaction Performance of Microcrystalline Cellulose

JRS PHARMA | 31-May-2016 | Technical / White Paper

Roller compaction, or dry granulation, is a manufacturing method for pharmaceutical and nutraceutical tablets that continues to gain importance. In order...

Early development screening for technology selection and formulation design

Capsugel | Recorded the 04-May-2016 | Webinar

In early formulation development of low solubility drugs, it is critical to identify the appropriate technology and produce promising formulations with...

White paper: ensure quality in novel dosage forms

Stable Micro Systems | 14-Mar-2016 | Technical / White Paper

From oral sprays to pastilles and capsules, pharmaceutical products must increasingly cater for a wider range of preferences. Download this free white...

High energetic and Phosgene reactions in safe hands

Valsynthese SA | 01-Mar-2016 | Technical / White Paper

Valsynthese, expert in high energetic and hazardous fine chemical production of key intermediates and APIs, is devoted to delivering high quality services...

Tablet Coating at Low Bed Temperatures with a Novel Coating Polymer

Roquette Pharma Solutions | 11-Jan-2016 | Case Study

This study shows how to obtain elegant, uniform coatings with zero visible defects and a practical coating solution for heat sensitive products!

Probiota 2016 Conference Programme

Probiota | 05-Jan-2016 | Event Programme

NutraIngredients’ Probiota is the leading annual event for the global prebiotic, probiotic and the microbiota focused food and pharma industries and in...

Excellence in Pharmaceutical Analysis

Butterworth | 01-Jan-2016 | Data Sheet

Butterworth specialise in Quality Control Analysis, Method Development, Validation & Stability Testing of Raw Materials, API, Finished Product and...

Maltitol in taste masking of acetaminophen chewable tablets: A synergy of combination

Roquette Pharma Solutions | 09-Nov-2015 | Technical / White Paper

Masking the bitter taste of acetaminophen in chewable tablets is always a challenge, especially in pediatric tablets where formulation possibilities are...

The Solid Dose, Latest News from Colorcon

Colorcon Inc. | 28-Sep-2015 | Data Sheet

With a commitment to serve customers through product innovation and technical excellence, Colorcon's Solid Dose newsletter brings you the latest insight...

Enhanced Sampling and Calibration Procedures for the Analysis of Residual Oxygen in Nitrogen Purged Pharmaceutical Packaging by GC-TCD

Butterworth | 23-Sep-2015 | Technical / White Paper

The classic Modified Atmosphere Packaging (MAP) application, in the pharmaceutical industry, uses medical grade nitrogen to purge atmospheric oxygen and...

Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

Roquette Pharma Solutions | 21-Sep-2015 | Research Study

The objective of this study was to evaluate the impact of Magnesium Stearate (MgSt) mixing conditions on the compaction behavior and disintegration time...

Evonik Solutions for Alcohol Induced Dose Dumping

Evonik Health Care | Recorded the 10-Sep-2015 | Webinar

Details the physiology related to alcohol consumption and its subsequent impact on drug release. Effective formulation strategies for meeting the physiological...

β-Cyclodextrins as a Solubilization Tool for Insoluble APIs

Roquette Pharma Solutions | 23-Jun-2015 | Technical / White Paper

To find the right solubilization tool for poorly soluble active ingredients is a big challenge.Want to know how to increase the aqueous solubility of ...

Enhanced Residual Solvents Analysis: A Practical Approach to Sampling, Delivery, Storage and Analysis.

Butterworth | 12-May-2015 | Technical / White Paper

Samplestorage, handling anddelivery are as important in the determination of residual solvents as the analysis itself. This paper provides practical advice...

IDEAL CURES receives EXCiPACTTM Certification

Ideal Cures | 04-May-2015 | Press Release

IDEAL CURES PVT. LTD. becomes the 1st Indian company to receive EXCiPACTTM certificate for its 2 manufacturing sites at Jammu & Khambhat. Audit for...

Development of a coated ODT formulation

Roquette Pharma Solutions | 20-Apr-2015 | Case Study

Orally Disintegrating Tablets (ODTs) are patient friendly delivery systems being far more convenient than the traditional “tablet and a glass of water”....

GELITA® RXL technology prevents cross-linking

Gelita AG | 06-Apr-2015 | Data Sheet

The GELITA Pharmaceutical Competence Team has developed a new technology: GELITA® RXL (Reduced Cross-Linking gelatine) that adds extra value to gelatine...

A Method to Meet the New Ph Eur Ninhydrin-Positive Substances Requirement

Butterworth | 03-Feb-2015 | Technical / White Paper

The European Pharmacopeia (Ph Eur) is moving away from the historical thin layer chromatography technique for the determination of Ninhydrin-positive substances,...

Customized Biosimilarity Analytical Testing from Catalent

Catalent Pharma Solutions | 26-Jan-2015 | Technical / White Paper

Assessment of biosimilar molecules requires an orthogonal analytical approach.  Any one particular analytical technique is not able to fully define the...

OptiPact™ Technology Introduced by Catalent

Catalent Pharma Solutions, the leading global provider of advanced delivery technologies and development solutions for drugs, biologics and consumer health...

Maximize Excipient Purity to Optimize Efficacy

Croda Inc | 29-Sep-2014 | Information Request

The purity of your excipient can have a profound impact on your formulation’s performance, affecting both the stability of the drug and the final formulation....

Nondestructive, single tablet analysis

Metrohm – customized analysis for the pharmaceutical industry | 16-Jun-2014 | Application Note

NIRS Spectroscopy allows rapid (<30 s) and nondestructive screening of solid dosage forms. It requires neither sample preparation nor solvent use. Interferences...

Developing textures with DC Polyols

Roquette Pharma Solutions | 16-Jun-2014 | Case Study

Different methodologies for assessing the texture and organoleptic properties of chewable polyols-based tablets.

Determination of moisture in a protein sample using a portable NIR instrument

Thermo Fisher Scientific | 03-Jun-2014 | Application Note

Near infrared spectroscopy has been used effectively to measure moisture in a wide variety of samples. Due to the large overtone band for water in NIR,...

Smart strategies for sustained release matrix tablets: Compritol® 888 ATO

Gattefossé | 19-May-2014 | Technical / White Paper

This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical,...

Benzocaine Degradation in Orodispersible Tablet (ODT) Platforms

Roquette Pharma Solutions | 12-May-2014 | Research Study

The goal of this study was to determine the effect of different marketed ODT platforms on the chemical stability of an amino-containing drug.The results...

Elemental Impurity Analysis in Pharmaceuticals

Butterworth | 06-May-2014 | Technical / White Paper

A method to identify the presence of heavy metals in pharmaceuticals was introduced in the United States Pharmacopoeia more than 100 years ago. Today pharmaceutical...

Near-infrared spectroscopy

Metrohm – customized analysis for the pharmaceutical industry | 01-May-2014 | Application Note

NIRSystems Technology:  Improved productivity and faster quality control of starting materials, intermediates and final products. Learn more

CREMER OLEO has become the holder of the first CEP ever granted for a Medium-Chain Triglyceride (MIGLYOL® 812 N).

CREMER OLEO GmbH & Co. KG | 28-Apr-2014 | Press Release

CREMER OLEO has gathered its activities for the pharmaceutical industry under the roof of CREMER Health, with a strong commitment to quality leadership...

Solving flowability, sticking and hardness problems

Roquette Pharma Solutions | 07-Apr-2014 | Case Study

The aim of this study was to improve a wet granulation based tablet formulation presenting flowability and sticking problems.A DC based formulation enabled...