Q Chip scaling up cGMP production using new funding

By Nick Taylor

- Last updated on GMT

Related tags Finance Investment

Q Chip is using new funding to scale up its Q-Sphera technology for cGMP production of sustained release peptide and protein therapeutics.

Securing an initial £2m ($3.1m) of a planned £3m funding round allows Q Chip to invest in scale-up of current good manufacturing practice (cGMP) compliant production of materials for preclinical development.

With this funding in hand, Q Chip is now able to establish manufacturing capability, a major milestone for our programmes. It will also allow the development of a sustainable pipeline of partnered programmes​”, said Ken Powell, executive chairman of Q Chip.

cGMP production

Production occurs in MicroPlant, a semi-continuous microfluidic device for the bioencapsulation of biological materials within polymer microspheres. Using MicroPlant Q Chip can produce solid, monodisperse microspheres.

The device forms droplets by combining dissolved polymer and peptide with a biocompatible oil at an engineered junction. Droplets are then frozen by passing from the ambient section into a cooler area. The final step is extraction which uses an anti-solvent to remove the microspheres.

Q Chip claims MicroPlant offers encapsulation efficiency of up to 95 per cent, very low inter-batch variability, reduced production costs and quantitative product recovery. Production is scaled up without compromising sphere uniformity by increasing the number of fluidic channels.

Characteristics and products

Using MicroPlant Q Chip can produce 80-200µm microspheres. The size of a microsphere affects administration and drug release kinetics. Consequently, by controlling their size Q Chip is able to modify drug release.

Preclinical development of biosimilars Q-Leuprolide, for prostate cancer and endometriosis, and Q-Octreotide, a treatment for acromegaly, will be supported by the capacity expansion. Q Chip plans to begin a bioequivalence study of Q-Leuprolide in 2011.

The financing round was led by Curzon Park Capitol and Finance Wales. Jon Moulton and Harry Solomon also invested in the company. To date Q Chip has secured investment totalling £7.5m.

in-PharmaTechnologist was unable to obtain additional information from Q Chip in time for publication.

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