Sigma-Aldrich introduces its signal transduction protein array for
high-throughput functional screening, which is set to play a major
role in identifying proteins that are involved in cellular
processes including proliferation, differentiation...
A new drug discovery technique, which uses mixed-mode sorbents in
process chromatography, has the potential to significantly reduce
costs and environmental burdens, especially in the protein
purification process.
SAFC Biosciences has unveiled an analogue of insulin specifically
designed for the large-scale manufacturing of recombinant
biopharmaceuticals, promising security of supply and product
consistency.
Sigma-Aldrich launches an online tool consisting of data detailing
biological pathways that provides an online resource to those in
the drug industry interested in first-in-class range, including
small molecules, antibodies, enzymes,...
Olympus has unveiled a working concept of what is claimed is the
next generation in fluorescence in vivo imaging systems by enabling
time-lapse and live imaging of emitted light from labelled
processes and tissues.
US biologics contract manufacturer Omnia Biologics has announced a
master services agreement to provide drug development company
Intradigm with process development and current good manufacturing
practice (cGMP) services for cancer...
A new method has revealed that a discovery involving menthol could
point towards new therapies to treat chronic inflammatory and
neuropathic pain indications by targeting the temperature-activated
ion channels.
Celera Genomics has announced that Abbott has selected two
additional cancer targets for further development, which brings the
total of targets to four under investigation as a result of the
collaboration between the companies to...
Swiss outsourcing company Lonza has granted biotechnology firm
Genentech a non-exclusive, worldwide license to their Glutamine
Synthetase (GS) Gene Expression System which offers better yields,
speed and stability in cell protein...
A consortium of US scientists have developed and evaluated a robust
new system for analysing how drugs bind to proteins, which could
speed up the delivery of potential new drugs and improve existing
ones.
Warwick Effect Polymers (WEP) have chosen R&D outsourcing
specialist Avantium to jointly develop their polyethylene glycol
PolyPEG technology for biopharmaceutical compounds, enhancing their
bioavailability and pharmacokinetics.
Waters Corporation has introduced new capabilities for proteomic
research by enhancing its bioanalysis software, which will allow
researchers to identify and quantify proteins and biomarkers more
efficiently.
Nanotechnology company Nanotrope has been awarded a $600,000
(€500,000) Small Business Innovation Research (SBIR) Phase 2 grant
from NASA for its research in nanoscale droplet technology, which,
apart from the agency's deep space...
Sigma Aldrich has launched a new integrated lysis and affinity
purification (iLAP) column, which greatly simplifies the process of
cell lysis and histidine-tagged protein purification into one step,
allowing fast, efficient and non-denaturing...
Chromos has announced an expansion to an existing Pfizer
collaboration, which builds on research focusing on genetic
engineering of production cell lines with multiple genes to improve
bioreactor performance and reduce monoclonal...
Nastech have found four new classes of lipids that can be used to
enhance transmucosal drug delivery and open up new opportunities
for non-injectable forms of drugs that would otherwise require
injections.
Research undertaken by Nastech has uncovered that endothelial tight
junctions play a role in atherosclerosis, which may provide new
therapeutic targets for cardiovascular disease.
Cresset Biomolecular Discovery has launched a technology that
identifies the 3-dimensional bound conformation of hits and
potential drugs in a biological target, assisting scientists
involved in ion channel research.
Clontech has announced a new addition to its TALON chemistry range,
which uses magnetic bead technology to separate microscale
quantities of protein when placed on a magnetic separator.
GE Healthcare has announced the availability of its single-use spin
column designed for purification of histidine-tagged proteins using
a standard microcentrifuge. It saves researchers time as it
achieves direct protein purification...
Researchers have shown how protein synthesis is targeted to certain
regions of a cell, a process crucial for the cellular motility,
which could form a basis for producing a drug that could force
tumour cells to express this protein,...
Researchers have identified two proteins involved in the process
that controls plant growth, which may help explain why human cells
reject chemotherapy drugs and could form a basis for new oncology
drugs.
Millipore Corporation today announced two tangential flow
filtration (TFF) products that allow researchers to efficiently
purify large volumes of protein-containing solutions that
accelerate drug screening and improve sample preparation.
Innovative laboratory technology that produces a sharper picture of
the nano-machine that translates genetic program into proteins
gives a unique insight into how some types of antibiotics work
leading to the design of better ones.
Varian has announced it is to acquire Polymer Laboratories for $42
million (€35.7 million)in a transaction that adds consumables and
instrumentation for Gel Permeation Chromatography (GPC) analysis to
its product portfolio.
Biolex Therapeutics and Kringle Pharma have announced a
collaboration for the production of a novel protein targeting
cancer. The protein is thought to be inefficient to produce with
traditional expression systems.
Scientists have synthesised a lab-made version of a human protein,
which alleviates symptoms of both acute and chronic arthritis. The
study opens new research avenues to better understand and develop
drug treatments for rheumatoid...
According to a recent report, the emerging market for protein
microarrays will experience strong growth buoyed on by the
emergence of the technology's ability to detect protein expression
more quickly and easily than traditional...
A US researcher has provided one possible molecular explanation of
how IGF-1 receptor and the IRS-1 protein act as a key growth factor
that regulates cell and body size. The discovery has revealed
details as to how tumour cells proliferate...
A discovery by scientists may provide a novel method to generate
proteins, providing an effective way of generating therapeutic
enzymes and other medically important proteins to produce novel
drugs.
Researchers have developed a unique approach that predicts protein
separation behaviour. The approach may reduce the time it takes to
bring pharmaceuticals to market and may have significant
implications for drug discovery.
Researchers at Rensselaer Polytechnic Institute in the US have
developed a method to predict protein separation behaviour -
directly from protein structure - that could reduce the time it
takes to bring pharmaceuticals to market.
Gentel Biosurfaces have signed a supply and marketing license
agreement with Kreatech Biotechnology to regarding the sales of ULS
reagents for protein labelling and use on single capture antibody
chips.
Researchers have discovered that a protein, which acts as a
fundamental inhibitor of cell movement or migration, may be a
likely target for new drug development aimed at decreasing tumour
metastasis, or spread, throughout the body.
Invitrogen Corporation has acquired the publicly held life sciences
company BioSource International in a transaction totalling
approximately $130 million. This deal adds to Invitrogen's growing
collection of protein and primary...
Oral drug delivery specialists, Merrion Pharmaceuticals, have been
issued with a patent that covers new peptide compounds which can be
physically or chemically complexed with an active substance, either
a drug or a biological, in...
French biotechnology company Proteus is launching a business unit
to provide protein engineering and production services for the life
science industry.
Sigma Aldrich has launched a new kit, which incorporates a novel
approach for the fluorescent quantification of proteins offering
numerous advantages over existing kits that include reversible
covalent binding, large dynamic range,...
Agilent Technologies introduces a high-capacity human protein
removal system for proteomics research, that removes up to 99 per
cent of the six most common proteins from human blood serum.
Lexicon Genetics and Xoma have announced the formation of a
collaboration to jointly develop and commercialise antibody drugs
that could be effective in treating diet-induced obesity and
enhanced insulin sensitivity.
In the US, the National Institutes of Health has awarded $88.9
million in grants to nine institutions over three years to
establish a collaborative research network that will use high-tech
screening methods to identify small molecules...
Scientists have successfully achieved the production of a
functional humanised antibody in the whites of eggs laid by a
transgenic hen, opening the door to using transgenic flocks as an
alternative to mammalian cell culture for the...
Dynal Biotech has announced two product releases from its new
proteomic preparation range, which use magnetic bead chromatography
technology to prepare for mass spectrum analysis without the
requirement of columns.
GWC Technologies claims that its new SpotReady chips enable labs to
carry out label-free array analysis of proteins and other
biomolecules, reports Anthony Fletcher.
Bruker Daltonics introduces a novel protein post translational
modification (PTM) discovery tool that represents the first
commercially available Electron Transfer Dissociation (ETD) module
for PTM discovery and de novo peptide sequencing...
Qiagen and Procognia have entered into a marketing and licensing
agreement, which targets the emerging field of protein
glycoanalysis. The combination of Qproteome products with
Procognia's On-Chip Glycoanalysis technology aims...
US firm Codexis and Shasun Chemicals and Drugs of India have signed
a manufacturing and supply agreement for a pharmaceutical
intermediate for a generic drug.
Wyatt Technology is set to offer its first integrated solution for
batch dynamic light scattering, which are amongst a batch of
products set to bring improved high throughput screening and better
understanding of the physical attributes...
A research program has released a small molecule binding annotation
and comparison tool, which is expected to accelerate lead
development in antimicrobial drug discovery, as well as allow
chemists to develop safer, more specific...
Varian has introduced a nuclear magnetic resonance (NMR) probe that
for the first time can be used to determine the molecular
structures of proteins and other biomolecules in the solid state.