Certara updates population-based simulator

By Melissa Fassbender

- Last updated on GMT

(Image: iStock/agsandrew)
(Image: iStock/agsandrew)

Related tags Clinical trial

The updated Simcyp Simulator features several enhanced models to help predict pharmacokinetic outcomes in virtual patient populations.

Version 16 of Certara’s Simcyp Population-based Simulator, includes enhanced lung, pediatric, and GI transit models, as well as a new dermal absorption model, and a new report assistant.

Certara Senior Vice President, Ellen Leinfuss, told us drug developers and regulators are increasingly relying on​ mechanistic modeling, “specifically physiologically-based pharmacokinetic (PBPK) modeling, to provide valuable information relating to clinical trial design, the need for specific clinical trials, formulation design, dosing in special populations, and drug-drug interactions (DDIs)​.”

According to Leinfuss, the Simulator provides a better understanding​ of PK, DDI, food effect, the role of enzymes and/or transporters, and the effect of polymorphisms and ethnic differences.

It enables us to study special populations, including pregnant women, renal- or hepatic-impaired, obese, geriatric or pediatric patients or those who have had bariatric surgery​,” she said.

Simcyp also provides a pediatric simulator that enables us to study how drugs will perform in children beginning with neonates. As organ development in children up to the age of two is non-linear, drug impact studies require this type of mechanistic modeling​.”

Parameter estimation and sensitivity analysis capabilities have also been expanded, and biologics models and a biologics database for the Monkey Simulator are now available.

Related news

Show more

Related products

show more

Saama accelerates data review processes

Saama accelerates data review processes

Content provided by Saama | 25-Mar-2024 | Infographic

In this new infographic, learn how Saama accelerates data review processes. Only Saama has AI/ML models trained for life sciences on over 300 million data...

More Data, More Insights, More Progress

More Data, More Insights, More Progress

Content provided by Saama | 04-Mar-2024 | Case Study

The sponsor’s clinical development team needed a flexible solution to quickly visualize patient and site data in a single location

Using Define-XML to build more efficient studies

Using Define-XML to build more efficient studies

Content provided by Formedix | 14-Nov-2023 | White Paper

It is commonly thought that Define-XML is simply a dataset descriptor: a way to document what datasets look like, including the names and labels of datasets...

Related suppliers

Follow us