Roller improves cell culture yields

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Related tags: Cell culture, Dna

Cell culture equipment company Integra Biosciences has launched a
new roller system designed to improve the cultivation of adherent
and suspension cells.

The CELLROLL is a compact roller system that can be used for cell studies, cultivating cells or for producing cellular products such as antibodies and recombinant proteins on a research or laboratory scale.

In 2003, Integra introduced a novel cell culture bottle design - the CELLine - whoich has been shown in studies to boost the yield of recombinant proteins while reducing the requirements for nutrient media. The CELLROLL introduction aims to provide similar benefits for labs using conventional culture flasks.

To create the optimal cell growth conditions the CELLROLL uses motor driven ball bearing rollers that gradually and smoothly implement movement minimising detrimental vibration and shear forces. The motor has been specially selected to ensure no heat is transferred into the incubator. Bottle racks are modular with one power unit controlling up to 8 racks or 16 roller bottles. The unit accommodates roller bottles with volumes of 300-400ml.

A control unit is programmable with regard to spin direction and motion (continuous spin or oscillation), bottle angle, speed and interval cycles for precise control during the growth phase. And the control board can remain outside the CO2 incubator allowing for changes to the programme without opening the incubator door.

The entire unit is CO2 and moisture resistant and comes with a built in timer and alarm system to alert you to a problem before cells are lost. A printer port is available for printing of protocols and documentation, and the complete unit comes with a drive motor, control unit and two modular stackable decks, according to the company.

Two models are available with rotation speeds of either 1-2 rpm or a faster motor at 2-6 rpm depending on your cell type. The racks can fit horizontally or vertically in most CO2 incubators.

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