Tapestry has presented data that supports the oral bioavailability
and antitumour activity of its drug candidate designed to overcome
multi-drug resistance in solid tumours that have become resistant
to taxane therapy.
Researchers have been working on a better laboratory method of
detecting ovarian cancer, which is set to improve on routine
screening that is currently available to women by improving
sensitivity to detect the cancer in its earliest...
Scientists in the US have found out how the enzyme helps initiate
the process that leads to colorectal cancer. Their discovery of a
new molecular mechanism by which an enzyme promotes cancer spread
may provide a new target at which...
A new report out today has revealed that the uptake of assays for
in-vitro diagnostics is being hindered due to a lack of knowledge
of this technology, in which its high sensitivity, specificity and
fast turn-around times has proved...
ExonHit and bioMirieux have announced that scientific data
generated in the detection of breast cancer could well lead to the
development of novel diagnostic tests that will enable the early
detection of breast cancer from blood.
A new discovery paves the way for new laboratory cancer research
after scientists have been able to explain just how a gene variant
carried in 15 per cent of the population may increase the risk of
developing cancer.
Anticipating a US Food and Drug Administration (FDA) approval this
year, Dendreon has awarded Diosynth Biotechnology with a long-term
contract to supply the recombinant protein antigen component of its
novel vaccine for prostate cancer...
The first clinical laboratory based test for saliva-based oral
cancer detection has been developed by scientists, who believe that
the clinical value this test demonstrates, could reduce the 350,000
- 400,000 new cases recorded each...
VGX and Dowpharma have signed an agreement to advance the
development of a novel cancer compound currently in pre-clinical
development that initial clinical studies will target individuals
with Non-Hodgkin's Lymphoma.
Last week's approval of Erbitux in the US breaks a 30-year drought
in treatments for head and neck cancer, a disease that kills 11,000
people in the US each year. Pharma giant Bristol-Myers Squibb (BMS)
and biotech company ImClone...
Scientists have discovered a new way that drugs can attach
themselves to DNA, providing a crucial step forward for those who
are developing drugs to combat cancer and other diseases. The
breakthrough heralds a new way of recognising...
Isis Pharmaceuticals and Rosetta Genomics has announced a joint
research collaboration to develop microRNA related therapies for
the treatment of liver cancer, demonstrating the therapeutic
potential of microRNA as a drug target...
Cambrex Bio Science has been given a contract to manufacture
Geron's GRNVAC1 telomerase vaccine for use in clinical trials and
will now transfer production to its Walkersville, Maryland
facility.
Two days after it filed for approval of Hecerptin for the treatment
of early-stage HER2-positive breast cancer in the US through its
majority-own biotechnology firm Genentech, Swiss drugmaker Roche
has followed suit in the EU, looking...
Pharmion and MethylGene has announced the formation of an
international licensing agreement potentially worth $272 million
(€224 million) for new class of compounds that inhibits gene
expression providing a tumour and haematological...
Pharmaceutical company, Phosphagenics, has announced the
commencement of animal studies on its anti-cancer compound, which
claims to destroy diseased cells while not affecting normal ones by
primarily acting as a signalling molecule...
Scientists have found an unusual lung-cancer tumour-suppressor
gene, which was shown to restore the inactivated gene slowing the
growth of tumour cells. Its importance in cancers of the lung and
head and neck may make it a viable...
A vibrating disc could have uses in laboratory diagnosis by
identifying and monitoring common types of cancer, providing
specialists with information about the most appropriate therapeutic
strategy.
CuraGen and TopoTarget have announced preliminary data suggesting
its small molecule candidate may have potential anti-tumour
activity against haematologic cancer.
Biovest International used the Cancer Research Institute's recent
meeting to debut its newest cell culture instrument, the
AutovaxID-C, which represents an advance in personalised medicine,
reducing the possibility of cross contamination,...
The question as to why some cancers resist drugs could be answered
by the discovery of new mechanisms, which delve deeper into how
cancer cells evolve to become resistant to various chemotherapy
drugs.
Stratagene announces a molecular diagnostics agreement, which aims
to focus on the growing molecular diagnostics market for infectious
diseases, currently worth $6.5 billion (€5.5 billion), expanding to
$12 billion by 2010 driven...
Increasing knowledge about how to manage the risks of gene therapy
is set to usher in a new era in disease therapies, with the
prospect of developing treatments in treating rare, inherited, or
life-threatening diseases very real.
A group of researchers have found that FLT-1 - a molecule
implicated in blood vessel growth - is necessary for the escape of
the leukaemia cells from the bone marrow (BM), suggesting that
blocking of this molecule pharmaceutically...
A small molecule drug, which has been developed to treat solid
tumour and haematological cancer, has entered an Investigational
New Drug (IND) application that represents the emergence of aurora
kinase inhibitors as a viable cancer...
pSivida has signed a licensing agreement with Beijing's Med-Pharm,
in a move that will facilitate distribution of BrachySil in China -
the world's fastest growing market for pharmaceuticals.
Scientists have admitted that an unexpected genetic phenomenon in
prostate cancer has changed conventional thinking over approaches
in drug treatment of breast, colon and lung malignancies.
According to a new report, more than 400 new medicines are in
development to treat diseases that affect US women, including 62
medicines now in testing to treat breast cancer.
US researchers have discovered how cancer cells communicate with
each other that is crucial to the tumour growth and motility of
cancer cells. By inhibiting this process via pharmaceutical
intervention, successful treatment of a range...
The selection of pharma and biotech companies reporting results for
the third quarter of 2005 provided mixed indications as to the
state of the industry. Pipeline product fruition may be returning
among the industries as DrugResearcher.com...
According to a new study, the worldwide market for in vitro cancer
diagnosis will reach the $7.4 billion (€6.1 billion) mark by 2009,
as the demand for such tests will continue to increase as new
cancer cases soars toward the 10 million...
Biolex Therapeutics and Kringle Pharma have announced a
collaboration for the production of a novel protein targeting
cancer. The protein is thought to be inefficient to produce with
traditional expression systems.
Researchers have discovered a species of seaweed that could yield
new compounds with pharmaceutical potential, some of which showed
the potential to kill cancer cells, bacteria and even the HIV
virus.
Scientists have demonstrated that a mouse virus that causes mammary
cancer can infect human cells. This latest study attempts to shed
light on a debate stretching back to the early 70's, which show
that a viral-like agent may...
Research scientists have targeted alterations in a human
chromosome, which can be used to improve the diagnosis and
treatment of brain tumours in adults that currently account for
over 50 per cent of primary tumours.
Researchers in the US have uncovered a contributing factor in
interferon resistance of malignant melanoma cells. The finding
represents a step forward in understanding of this type of cancer
and the changes in gene and cellular signalling...
Genentech has announced that studies of Avastin in
platinum-refractory ovarian cancer patients have been discontinued
due to patients developing a serious bowel problem.
A US researcher has provided one possible molecular explanation of
how IGF-1 receptor and the IRS-1 protein act as a key growth factor
that regulates cell and body size. The discovery has revealed
details as to how tumour cells proliferate...
MerLion Pharmaceuticals has entered into a large-scale screening
programme with Cancer Research Technology (CRT) to identify new
anti-cancer drug candidates derived from natural product chemistry.
US scientists have claimed to have developed the next generation of
effective viral-based therapies for cancer in which 'terminator'
viruses are deployed to destroy primary tumours.
Researchers in the US have constructed a new virus-based gene
therapy delivery system that has uses in cancer treatment. The
findings are said to provide a solution to the problems that have
hampered gene therapy treatments.
EntreMed has entered into a research and development agreement with
the National Cancer Institute (NCI) to evaluate the role of
HIF-1alpha inhibition in the treatment of cancer. The agreement
aims to establish the relationship between...
According to a new report nanotechnology tools for drug discovery
will grow from $580 million (€471.6 million) in 2004 to $1.1
billion in 2010, driven by corporate R&D and new commercial
applications.
US researchers have pinpointed a key molecule involved in
triggering rare but usually fatal cancers known as rhabdoid
tumours. This discovery could lead to novel therapies for these
tumours that mainly affect children.
US researchers have developed a nanoparticle-derived shell, which
they believe may some day target tumour cells and deliver
medication to specific locations. The polymer shell protection
ensures the drug can circulate longer without...
A group of researchers in the US have enhanced the abilities of
molecules they are creating to deliver medication to cancer cells.
The man-made molecular complexes enter cancer cells and, when
signalled, deliver killing medicine or...
Researchers have discovered a new tumour defence system that
interferes with the cells that are trying to kill them. These
results raise the possibility of new drug targets for cancer such
as those that may transport free fatty acids...
Scientists have discovered the genetic pathway responsible for
breast cancer growth, which details how the female hormone
oestrogen causes growth of breast cancer cells. In practical terms,
efforts can now be focused on developing...
Researchers have discovered that a protein, which acts as a
fundamental inhibitor of cell movement or migration, may be a
likely target for new drug development aimed at decreasing tumour
metastasis, or spread, throughout the body.
The possibilities nanotechnology has in drug and therapeutic
applications was demonstrated once again after researchers were
able to demonstrate the destruction of cancer cells whilst keeping
healthy tissue unharmed.