It appears that pharma heavyweight Pfizer has not emerged unscathed
from the contamination chaos that has affected EU supplies of HIV
drug Viracept (nelfinavir), with the company this week warning that
its version of the treatment...
Scientists have successfully used ribozymes - considered by some to
be the 'living fossils' of a time when life was based on RNA - to
prevent the spread of HIV in the body.
The significance of the aborted deal between GlaxoSmithKline and
Cobra has been exaggerated due to GSK's high profile and is not the
end of the world, the British contract manufacturer said.
A naturally occurring molecule helps protect the immune system from
being destroyed by HIV and could open up a new way of fighting the
effects of the virus, according to new research.
Researchers believe they have discovered how the HIV virus avoids
the human body's natural defences paving the way for a HIV-specific
cell drug treatment that vastly improves on the drugs that are
currently available.
Researchers have theorised that a peptide found in primates could
halt the HIV-1 virus from infecting blood cells. The discovery
could form the crux of an effective drug therapy, which may
overcome resistance exhibited by current...
Scientists believe they have made a breakthrough in the fight
against HIV drug resistance by developing a drug that is the first
in a new class of HIV drug candidates called Maturation Inhibitors.
European researchers have unlocked more secrets of how the HIV and
SARS virus operates, which if exploited could be the starting point
for a host of effective antiviral drugs that combat the virus'
mechanism of action.
A consortium of researchers has detailed the activity of a novel
drug compound that kills multiple HIV strains via a unique
mechanism of action. The discovery brings with it hope in using
this compound in both topical and systemic...
Scientists have taken a major step forward in the diagnosis and
treatment of HIV as it was revealed that the virus' 3D structure
had been constructed. This achievement will prove instrumental in
the development of more effective...
A diagnostic test, which monitors anti-HIV drugs in the blood, is
set to enter development to eventually become available across
Europe. The test will be used to identify the correct dosage of
medicine for individual patients.
Roche Molecular Systems and Primagen today entered talks to form a
collaboration that develops dry filter spot technology for HIV-1
viral load testing in the developing world.
According to new study, the virus that causes AIDS is becoming more
sensitive to drug treatments, contradicting a wealth of research
that demonstrates the emergence of drug resistant viral strains.
GlaxoSmithKline has halted clinical trials of its first-in-class
HIV drug after cases of hepatotoxicity was discovered in
treatment-naïve patients. The setback does not mean the end of
development for this drug candidate but suggests...
ViroLogic, announced the signing of a multi-year, $4.8 million (€4
million) service agreement with Schering-Plough Research Institute,
to use ViroLogic's novel HIV resistance testing technology to
support Schering-Plough's...
Gilead Sciences has announced the initiation of phase I/II clinical
trial evaluating its latest HIV drug treatment that represents a
promising novel class of agents with the potential to inhibit HIV
replication, particularly for patients...
An opportunity to develop drugs by targeting a recently discovered,
and potentially vulnerable, intermediate stage of the viral life
cycle, could result in a new pharmaceutical treatment in the fight
against HIV and other similar...
BioInvent become the latest company to enter the HIV/AIDS drug
arena after UK authorities gave the go ahead to commence the
company's first clinical trial of its human antibody to treat the
virus.
VIRxSYS has announced the completion of the phase I study of its
novel HIV gene therapy, which has been touted as the first of a
next-generation anti-HIV treatment involving gene therapy. The
positive results mean a phase II study...
VIRxSYS report the results of its latest clinical trial, testing
VRX496, a HIV-derived lentiviral vector that could represent a
novel HIV gene therapy. The trial results also showed patients with
multiple-drug resistant HIV responding...
The first documented case of drug resistant HIV has prompted calls
to step up HIV drug research after the victim developed full-blown
AIDS in just three months.
India begins its first ever human clinical trial of an
investigational vaccine candidate designed to treat HIV/AIDS, which
now has a worldwide infection rate of 14,000 every day.
Scientists have targeted the alkaloids of the quinolines chemical
family, which have proved effective against visceral leishmaniasis
treating this severe form of the disease with its antiparasitic
properties.
The need for an effective HIV drug became apparent as the US Food
and Drug Administration (FDA) granted Fast Track designation to the
first in a new class of HIV drugs called Maturation Inhibitors.
A new family of drugs specifically designed to inhibit nuclear
import of integrase, blocking viral replication of human
immunodeficiency virus type 1 (HIV-1) infected cells suggests an
approach that could be effective against drug...
The recent surge in HIV research shows no sign of terminating as
researchers reported the successful targeting of an HIV protein
that has eluded existing therapies. The technique used for
identifying the synthetic molecules may also...
Global efforts to develop a vaccine to treat HIV infection could be
derailed because investigators have not considered manufacturing
processes in the design of their candidates.
Researchers in the US are testing a new way to treat HIV by
destroying the virus as it enters host cells. The treatment is
based on the genetic manipulation of the immune cells that HIV
infects to enable them to destroy the virus.
Researchers in France have discovered how HIV hides itself from the
host immune system, raising the possibility of developing new drugs
or vaccines for the disease, reports Phil Taylor.
A series of new drugs to treat HIV infection which work in
different ways to available therapies are moving through clinical
trials, raising the hope that a new generation of antivirals is on
the horizon to treat resistant strains...
