Onyx invests in continuous flow following API demand

By Fiona BARRY

- Last updated on GMT

Onyx invests in continuous flow following API demand

Related tags: Contract research organization, Manufacturing

UK API-maker and contract research organisation (CRO) Onyx Scientific is installing equipment for continuous flow manufacturing to offer customers an alternative to batch manufacturing.

Denise Bowser, Commercial Director, told in-Pharmatechnologist.com the company has spent £80,000 ($137,000) on equipment for its premises in Sunderland, northeast England citing customer demand for flexibility during process development.

Pharmaceutical clients ask for continuous flow during product R&D, she said, for “a wider range of conditions for certain experiments,​” particularly surrounding hazardous reactions. “For us it’s a good thing to have the technology to give the clients full availability.​”

She added that continuous flow would make better use of the company’s space, give quicker output, and provide greater flexibility in compound manufacturing.

Continuous flow manufacturing – a technique that aims to lower costs and waste by integrating all stages of production – is “a very small area,​” Bowser told us. The majority of Onyx’s API manufacturing will continue to be batch work, she said; “we’re just giving our clients further scope for developing using different techniques.​”

API investment

The equipment purchase comes as part of a wider investment initiative, with Onyx announcing it is increasing its GMP manufacturing capacity with extra vessels, following increased demand for GMP API manufacturing services for drug development.

The company reported a 45% rise in solid-state chemistry-related revenues last year, which it said was driven by early stage campaigns.

In May this year, it completed an API manufacturing deal for US firm Neuronascent,​ producing a 1kg consignment for use in the neurology company’s marketing authorisation submission to the US Food and Drug Administration.

As well as its Sunderland-based laboratories, Onyx has access to seven API sites in India for technology transfer, pilot-scale work, and manufacturing for Phase II through to commercial.

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